Harnessing the Power of Force: Development of Mechanophores for Molecular Release

Brooke A. Versaw, Tian Zeng, Xiaoran Hu, Maxwell J. Robb

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Polymers that release small molecules in response to mechanical force are promising materials for a variety of applications ranging from sensing and catalysis to targeted drug delivery. Within the rapidly growing field of polymer mechanochemistry, stress-sensitive molecules known as mechanophores are particularly attractive for enabling the release of covalently bound payloads with excellent selectivity and control. Here, we review recent progress in the development of mechanophore-based molecular release platforms and provide an optimistic, yet critical perspective on the fundamental and technological advancements that are still required for this promising research area to achieve significant impact.

Original languageEnglish (US)
Pages (from-to)21461-21473
Number of pages13
JournalJournal of the American Chemical Society
Issue number51
StatePublished - Dec 29 2021
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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