TY - JOUR
T1 - Growth hormone, exercise, and athletic performance
T2 - A continued evolution of complexity
AU - Kraemer, William J.
AU - Dunn-Lewis, Courtenay
AU - Comstock, Brett A.
AU - Thomas, Gwendolyn A.
AU - Clark, James E.
AU - Nindl, Bradley C.
PY - 2010/7
Y1 - 2010/7
N2 - KRAEMER, W.J., C. DUNN-LEWIS, B.A. COMSTOCK, G.A. THOMAS, J.E. CLARK, and B.C. NINDL. Growth hormone, exercise, and athletic performance: a continued evolution of complexity. Curr. Sports Med. Rep., Vol. 9, No. 4, pp. 242Y252, 2010. Growth hormone (hGH) presents pleiotropic effects in many tissues encompassing a diverse range of physiological actions. Its complexity as a family of hormones with different isoforms and different somatotroph molecular functions continues to challenge the status quo of our understanding of its release, function, and signaling. Owing to the fact that the majority of the literature has viewed hGH from the perspective of the primary 22 kD monomer, further investigation is needed as to the influence and biological activity of other aggregate and splice variant isoforms that are released into circulation. Its role over the life span and with supplementation yields equivocal results with more study needed. Testing for the use of hGH has progressed, and the first positive test was recently documented. Understanding of pituitary function and physiology will remain complex until the use of a broader range of analytical techniques, including assays, becomes mainstream.
AB - KRAEMER, W.J., C. DUNN-LEWIS, B.A. COMSTOCK, G.A. THOMAS, J.E. CLARK, and B.C. NINDL. Growth hormone, exercise, and athletic performance: a continued evolution of complexity. Curr. Sports Med. Rep., Vol. 9, No. 4, pp. 242Y252, 2010. Growth hormone (hGH) presents pleiotropic effects in many tissues encompassing a diverse range of physiological actions. Its complexity as a family of hormones with different isoforms and different somatotroph molecular functions continues to challenge the status quo of our understanding of its release, function, and signaling. Owing to the fact that the majority of the literature has viewed hGH from the perspective of the primary 22 kD monomer, further investigation is needed as to the influence and biological activity of other aggregate and splice variant isoforms that are released into circulation. Its role over the life span and with supplementation yields equivocal results with more study needed. Testing for the use of hGH has progressed, and the first positive test was recently documented. Understanding of pituitary function and physiology will remain complex until the use of a broader range of analytical techniques, including assays, becomes mainstream.
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U2 - 10.1249/JSR.0b013e3181e976df
DO - 10.1249/JSR.0b013e3181e976df
M3 - Review article
C2 - 20622543
AN - SCOPUS:77956801652
SN - 1537-890X
VL - 9
SP - 242
EP - 252
JO - Current Sports Medicine Reports
JF - Current Sports Medicine Reports
IS - 4
ER -