Glucose attenuates the effect of combined muscarinic-nicotinic receptor blockade on spontaneous alternation

Michael E. Ragozzino, Gloria Arankowsky-Sandoval, Paul E. Gold

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Glucose administration reverses the effects of both muscarinic and nicotinic cholinergic receptor antagonists on memory and other measures. In experiment 1, we found that glucose attenuated impairments on spontaneous alternation after muscarinic (scopolamine, 0.5 mg/kg) or nicotonic (mecamylamine, 5.0 mg/kg) receptor blockade. In experiment 2, we examined whether glucose could reverse the spontaneous alternation impairments produced by combined muscarinic-nicotinic receptor blockade. Scopolamine (0.1 mg/kg) and mecamylamine (2.5 mg/kg) when administered separately did not modify alternation performance, but when coadministered they decreased spontaneous alternation scores. This decrease was attenuated by glucose at 100, 300, 500 and 3000 mg/kg. These findings suggest that glucose may attenuate the behavioral impairment by enhancing cholinergic activity and/or other neurotransmitter systems.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalEuropean Journal of Pharmacology
Volume256
Issue number1
DOIs
StatePublished - Apr 11 1994
Externally publishedYes

Keywords

  • Glucose
  • Mecamylamine
  • Memory
  • Scopolamine
  • Spontaneous alternaion

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Glucose attenuates the effect of combined muscarinic-nicotinic receptor blockade on spontaneous alternation'. Together they form a unique fingerprint.

Cite this