Glassy dynamics in three-dimensional embryonic tissues.

Eva Maria Schötz, Marcos Lanio, Jared A. Talbot, Mary Elizabeth Manning

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Many biological tissues are viscoelastic, behaving as elastic solids on short timescales and fluids on long timescales. This collective mechanical behaviour enables and helps to guide pattern formation and tissue layering. Here, we investigate the mechanical properties of three-dimensional tissue explants from zebrafish embryos by analysing individual cell tracks and macroscopic mechanical response. We find that the cell dynamics inside the tissue exhibit features of supercooled fluids, including subdiffusive trajectories and signatures of caging behaviour. We develop a minimal, three-parameter mechanical model for these dynamics, which we calibrate using only information about cell tracks. This model generates predictions about the macroscopic bulk response of the tissue (with no fit parameters) that are verified experimentally, providing a strong validation of the model. The best-fit model parameters indicate that although the tissue is fluid-like, it is close to a glass transition, suggesting that small changes to single-cell parameters could generate a significant change in the viscoelastic properties of the tissue. These results provide a robust framework for quantifying and modelling mechanically driven pattern formation in tissues.

Original languageEnglish (US)
Pages (from-to)20130726
Number of pages1
JournalJournal of the Royal Society Interface
Volume10
Issue number89
StatePublished - Dec 6 2013

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Tissue
Fluids
Zebrafish
Glass
Glass transition
Embryonic Structures
Trajectories
Mechanical properties

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Glassy dynamics in three-dimensional embryonic tissues. / Schötz, Eva Maria; Lanio, Marcos; Talbot, Jared A.; Manning, Mary Elizabeth.

In: Journal of the Royal Society Interface, Vol. 10, No. 89, 06.12.2013, p. 20130726.

Research output: Contribution to journalArticle

Schötz, EM, Lanio, M, Talbot, JA & Manning, ME 2013, 'Glassy dynamics in three-dimensional embryonic tissues.', Journal of the Royal Society Interface, vol. 10, no. 89, pp. 20130726.
Schötz, Eva Maria ; Lanio, Marcos ; Talbot, Jared A. ; Manning, Mary Elizabeth. / Glassy dynamics in three-dimensional embryonic tissues. In: Journal of the Royal Society Interface. 2013 ; Vol. 10, No. 89. pp. 20130726.
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