Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity

Alfonso Abizaid, James L. Hougland

Research output: Contribution to journalReview article

Abstract

Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues involving appetite, weight gain, obesity, and related metabolic disorders, and may be an option for patients suffering from wasting conditions like cachexia. In this review, we summarize recent developments in the biochemistry of ghrelin and GHS-R1a signaling. These include unravelling the enzymatic transformations that generate active ghrelin and the discovery of multiple proteins that interact with ghrelin and GHS-R1a to regulate signaling. Furthermore, we propose that harnessing these processes will lead to highly selective treatments to address obesity, diabetes, and other metabolism-linked disorders.

Original languageEnglish (US)
JournalTrends in Endocrinology and Metabolism
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Ghrelin Receptor
Ghrelin
Obesity
Cachexia
Appetite
Biochemistry
Weight Gain
Pharmacology
Health
Proteins

Keywords

  • diabetes
  • energy balance
  • ghrelin
  • ghrelin O-acyltransferase
  • GHS-R1a
  • GPCR dimers
  • LEAP2
  • obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Ghrelin Signaling : GOAT and GHS-R1a Take a LEAP in Complexity. / Abizaid, Alfonso; Hougland, James L.

In: Trends in Endocrinology and Metabolism, 01.01.2019.

Research output: Contribution to journalReview article

@article{931b34e35d8d47e9ad970f62977ec793,
title = "Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity",
abstract = "Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues involving appetite, weight gain, obesity, and related metabolic disorders, and may be an option for patients suffering from wasting conditions like cachexia. In this review, we summarize recent developments in the biochemistry of ghrelin and GHS-R1a signaling. These include unravelling the enzymatic transformations that generate active ghrelin and the discovery of multiple proteins that interact with ghrelin and GHS-R1a to regulate signaling. Furthermore, we propose that harnessing these processes will lead to highly selective treatments to address obesity, diabetes, and other metabolism-linked disorders.",
keywords = "diabetes, energy balance, ghrelin, ghrelin O-acyltransferase, GHS-R1a, GPCR dimers, LEAP2, obesity",
author = "Alfonso Abizaid and Hougland, {James L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.tem.2019.09.006",
language = "English (US)",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier",

}

TY - JOUR

T1 - Ghrelin Signaling

T2 - GOAT and GHS-R1a Take a LEAP in Complexity

AU - Abizaid, Alfonso

AU - Hougland, James L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues involving appetite, weight gain, obesity, and related metabolic disorders, and may be an option for patients suffering from wasting conditions like cachexia. In this review, we summarize recent developments in the biochemistry of ghrelin and GHS-R1a signaling. These include unravelling the enzymatic transformations that generate active ghrelin and the discovery of multiple proteins that interact with ghrelin and GHS-R1a to regulate signaling. Furthermore, we propose that harnessing these processes will lead to highly selective treatments to address obesity, diabetes, and other metabolism-linked disorders.

AB - Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues involving appetite, weight gain, obesity, and related metabolic disorders, and may be an option for patients suffering from wasting conditions like cachexia. In this review, we summarize recent developments in the biochemistry of ghrelin and GHS-R1a signaling. These include unravelling the enzymatic transformations that generate active ghrelin and the discovery of multiple proteins that interact with ghrelin and GHS-R1a to regulate signaling. Furthermore, we propose that harnessing these processes will lead to highly selective treatments to address obesity, diabetes, and other metabolism-linked disorders.

KW - diabetes

KW - energy balance

KW - ghrelin

KW - ghrelin O-acyltransferase

KW - GHS-R1a

KW - GPCR dimers

KW - LEAP2

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85073812503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073812503&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2019.09.006

DO - 10.1016/j.tem.2019.09.006

M3 - Review article

C2 - 31636018

AN - SCOPUS:85073812503

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

ER -