Germline cysts: A conserved phase of germ cell development?

Melissa E. Pepling, Margaret De Cuevas, Allan C. Sprading

Research output: Contribution to journalReview articlepeer-review

216 Scopus citations


Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction with morphological evidence, suggest that the process is highly conserved during evolution. This article discusses these recent findings and argues that cysts play an important and general role in germ line development.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalTrends in Cell Biology
Issue number7
StatePublished - Jul 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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