Genomic sister-disorders of neurodevelopment: An evolutionary approach

Bernard Crespi, Kyle Summers, Steve Dorus

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Genomic sister-disorders are defined here as diseases mediated by duplications versus deletions of the same region. Such disorders can provide unique information concerning the genomic underpinnings of human neurodevelopment because effects of diametric variation in gene copy number on cognitive and behavioral phenotypes can be inferred. We describe evidence from the literature on deletions versus duplications for the regions underlying the best-known human neurogenetic sister-disorders, including Williams syndrome, Velocar- diofacial syndrome, and Smith-Magenis syndrome, as well as the X-chromo- somal conditions Klinefelter and Turner syndromes. These data suggest that diametric copy-number alterations can, like diametric alterations to imprinted genes, generate contrasting phenotypes associated with autistic-spectrum and psychotic-spectrum conditions. Genomically based perturbations to the development of the human social brain are thus apparently mediated to a notable degree by effects of variation in gene copy number. We also conducted the first analyses of positive selection for genes in the regions affected by these disorders. We found evidence consistent with adaptive evolution of protein-coding genes, or selective sweeps, for three of the four sets of sister-syndromes analyzed. These studies of selection facilitate identification of candidate genes for the phenotypes observed and lend a novel evolutionary dimension to the analysis of human cognitive architecture and neurogenetic disorders.

Original languageEnglish (US)
Pages (from-to)81-100
Number of pages20
JournalEvolutionary Applications
Volume2
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Keywords

  • Autism
  • Evolution
  • Gene copy-number variation
  • Positive Darwinian selection
  • Schizophrenia

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

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