Genetics of intercellular signalling in C. elegans

J. Austin, E. M. Maine, J. Kimble

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Cell-cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans. It has been found that two genes, glp-1 and lin-12, are required for many of these decisions. glp-1 is required for induction of mitotic proliferation in the germline by the somatic distal tip cell and for induction of the anterior pharynx early in embryogenesis. lin-12 is required for the interactions between cells of equivalent developmental potential, which allow them to take on different fates. Comparison of these two genes on a molecular level indicates that they are similar in sequence and organization, suggesting that the mechanisms of these two different sets of cell-cell interactions are similar.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalDevelopment
Volume107
Issue numberSUPPL.
StatePublished - 1989

Keywords

  • Caenorhabditis elegans
  • cell fate
  • cell-cell interaction
  • glp-1
  • lin-12

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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    Austin, J., Maine, E. M., & Kimble, J. (1989). Genetics of intercellular signalling in C. elegans. Development, 107(SUPPL.), 53-57.