GDF15 Induces Anorexia through Nausea and Emesis

Tito Borner, Evan D. Shaulson, Misgana Y. Ghidewon, Amanda B. Barnett, Charles C. Horn, Robert P. Doyle, Harvey J. Grill, Matthew R. Hayes, Bart C. De Jonghe

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew (Suncus murinus) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.

Original languageEnglish (US)
Pages (from-to)351-362.e5
JournalCell Metabolism
Issue number2
StatePublished - Feb 4 2020


  • GDF15
  • MIC-1
  • Suncus murinus
  • anorexia
  • chemotherapy
  • emesis
  • malaise
  • nausea
  • obesity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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