GDF15 Induces Anorexia through Nausea and Emesis

Tito Borner; Evan D. Shaulson; Misgana Y. Ghidewon; Amanda B. Barnett; Charles C. Horn; Robert P. Doyle; Harvey J. Grill; Matthew R. Hayes; Bart C. De Jonghe

doi:10.1016/j.cmet.2019.12.004

GDF15 Induces Anorexia through Nausea and Emesis

Tito Borner, Evan D. Shaulson, Misgana Y. Ghidewon, Amanda B. Barnett, Charles C. Horn, Robert P. Doyle, Harvey J. Grill, Matthew R. Hayes, Bart C. De Jonghe

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew (Suncus murinus) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.

Original language	English (US)
Pages (from-to)	351-362.e5
Journal	Cell Metabolism
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2019.12.004
State	Published - Feb 4 2020

Keywords

GDF15
GFRAL
MIC-1
Suncus murinus
anorexia
chemotherapy
emesis
malaise
nausea
obesity

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.12.004

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title = "GDF15 Induces Anorexia through Nausea and Emesis",

abstract = "This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew (Suncus murinus) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.",

keywords = "GDF15, GFRAL, MIC-1, Suncus murinus, anorexia, chemotherapy, emesis, malaise, nausea, obesity",

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AU - Borner, Tito

AU - Shaulson, Evan D.

AU - Ghidewon, Misgana Y.

AU - Barnett, Amanda B.

AU - Horn, Charles C.

AU - Doyle, Robert P.

AU - Grill, Harvey J.

AU - Hayes, Matthew R.

AU - De Jonghe, Bart C.

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Y1 - 2020/2/4

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AB - This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew (Suncus murinus) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.

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KW - MIC-1

KW - Suncus murinus

KW - anorexia

KW - chemotherapy

KW - emesis

KW - malaise

KW - nausea

KW - obesity

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GDF15 Induces Anorexia through Nausea and Emesis

Abstract

Keywords

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