GDF15 Induces Anorexia through Nausea and Emesis

Tito Borner, Evan D. Shaulson, Misgana Y. Ghidewon, Amanda B. Barnett, Charles C. Horn, Robert P. Doyle, Harvey J. Grill, Matthew R. Hayes, Bart C. De Jonghe

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew (Suncus murinus) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.

Original languageEnglish (US)
Pages (from-to)351-362.e5
JournalCell Metabolism
Volume31
Issue number2
DOIs
StatePublished - Feb 4 2020

Keywords

  • GDF15
  • GFRAL
  • MIC-1
  • Suncus murinus
  • anorexia
  • chemotherapy
  • emesis
  • malaise
  • nausea
  • obesity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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    Borner, T., Shaulson, E. D., Ghidewon, M. Y., Barnett, A. B., Horn, C. C., Doyle, R. P., Grill, H. J., Hayes, M. R., & De Jonghe, B. C. (2020). GDF15 Induces Anorexia through Nausea and Emesis. Cell Metabolism, 31(2), 351-362.e5. https://doi.org/10.1016/j.cmet.2019.12.004