Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection

Jeremy L. Steinbacher; Sherrill A. Lathrop; Kai Cheng; Jedd M. Hillegass; Kelly J. Butnor; Risto A. Kauppinen; Brooke T. Mossman; Christopher C. Landry

doi:10.1002/smll.201001447

Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection

Jeremy L. Steinbacher, Sherrill A. Lathrop, Kai Cheng, Jedd M. Hillegass, Kelly J. Butnor, Risto A. Kauppinen, Brooke T. Mossman, Christopher C. Landry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.

Original language	English (US)
Pages (from-to)	2678-2682
Number of pages	5
Journal	Small
Volume	6
Issue number	23
DOIs	https://doi.org/10.1002/smll.201001447
State	Published - Dec 6 2010
Externally published	Yes

Keywords

Biomedical applications
Magnetic resonance imaging
Mesoporous materials
Particle excretion
Silica

ASJC Scopus subject areas

General Chemistry
Engineering (miscellaneous)
Biotechnology
General Materials Science
Biomaterials

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10.1002/smll.201001447

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title = "Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection",

abstract = "To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.",

keywords = "Biomedical applications, Magnetic resonance imaging, Mesoporous materials, Particle excretion, Silica",

author = "Steinbacher, {Jeremy L.} and Lathrop, {Sherrill A.} and Kai Cheng and Hillegass, {Jedd M.} and Butnor, {Kelly J.} and Kauppinen, {Risto A.} and Mossman, {Brooke T.} and Landry, {Christopher C.}",

year = "2010",

month = dec,

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doi = "10.1002/smll.201001447",

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journal = "Small",

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T2 - In vivo imaging of microparticles after intraperitoneal injection

AU - Steinbacher, Jeremy L.

AU - Lathrop, Sherrill A.

AU - Cheng, Kai

AU - Hillegass, Jedd M.

AU - Butnor, Kelly J.

AU - Kauppinen, Risto A.

AU - Mossman, Brooke T.

AU - Landry, Christopher C.

PY - 2010/12/6

Y1 - 2010/12/6

N2 - To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.

AB - To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.

KW - Biomedical applications

KW - Magnetic resonance imaging

KW - Mesoporous materials

KW - Particle excretion

KW - Silica

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Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection

Abstract

Keywords

ASJC Scopus subject areas

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