Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection

Jeremy L. Steinbacher, Sherrill A. Lathrop, Kai Cheng, Jedd M. Hillegass, Kelly J. Butnor, Risto A. Kauppinen, Brooke T. Mossman, Christopher C. Landry

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.

Original languageEnglish (US)
Pages (from-to)2678-2682
Number of pages5
JournalSmall
Volume6
Issue number23
DOIs
StatePublished - Dec 6 2010
Externally publishedYes

Keywords

  • Biomedical applications
  • Magnetic resonance imaging
  • Mesoporous materials
  • Particle excretion
  • Silica

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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    Steinbacher, J. L., Lathrop, S. A., Cheng, K., Hillegass, J. M., Butnor, K. J., Kauppinen, R. A., Mossman, B. T., & Landry, C. C. (2010). Gd-labeled microparticles in MRI: In vivo imaging of microparticles after intraperitoneal injection. Small, 6(23), 2678-2682. https://doi.org/10.1002/smll.201001447