TY - JOUR
T1 - Gd-labeled microparticles in MRI
T2 - In vivo imaging of microparticles after intraperitoneal injection
AU - Steinbacher, Jeremy L.
AU - Lathrop, Sherrill A.
AU - Cheng, Kai
AU - Hillegass, Jedd M.
AU - Butnor, Kelly J.
AU - Kauppinen, Risto A.
AU - Mossman, Brooke T.
AU - Landry, Christopher C.
PY - 2010/12/6
Y1 - 2010/12/6
N2 - To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.
AB - To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.
KW - Biomedical applications
KW - Magnetic resonance imaging
KW - Mesoporous materials
KW - Particle excretion
KW - Silica
UR - http://www.scopus.com/inward/record.url?scp=78649974584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649974584&partnerID=8YFLogxK
U2 - 10.1002/smll.201001447
DO - 10.1002/smll.201001447
M3 - Article
C2 - 21069757
AN - SCOPUS:78649974584
SN - 1613-6810
VL - 6
SP - 2678
EP - 2682
JO - Small
JF - Small
IS - 23
ER -