Floating-reference method of noninvasive blood glucose concentration measurement

The principle of the noninvasive blood glucose concentration measurement with floating-reference method was introduced. By Monte Carlo simulation, the existing condition of the radial reference location was studied, which was the key factor of the floating-reference method. At the reference location, the diffuse reflectance light is not sensitive to the variation of glucose, thus it can be used as an internal reference to diminish the influence of the physiological background change. Using the Intralipid solutions with different background, the preliminary experimental validation of the floating-reference method was conducted. The results show that after the spectra data are processed by the floating-reference method, the influence induced by the change of measuring circumstance and the variation of Intralipid background is diminished effectively, and the resolving capability on glucose concentration is greatly enhanced.