Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate

Hang Zhou; Naoto Isozaki; Kazuki Ukita; Taviare L. Hawkins; Jennifer L. Ross; Ryuji Yokokawa

doi:10.1109/NEMS50311.2020.9265570

Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate

Hang Zhou, Naoto Isozaki, Kazuki Ukita, Taviare L. Hawkins, Jennifer L. Ross, Ryuji Yokokawa

Research output: Chapter in Book/Entry/Poem › Conference contribution

Abstract

Microtubules (MTs) are highly dynamic tubular biopolymers, involving in many cellular processes such as intracellular transport, cellular structure maintenance, and cell division. All the processes require that MTs have adequate and adjustable flexural rigidity to cope with different functions. Despite the importance of MT mechanics, previously reported values of MTs' flexural rigidity vary significantly. Here we provide an explanation for such a longstanding discrepancy. Moreover, with the localization precision optimized to the nanometer-level, we find that the flexural rigidity of MTs is dependent on growth rate. Not only do our results show the importance of localization precision on flexural rigidity studies, but also highlight the significance of the MT growth rate.

Original language	English (US)
Title of host publication	15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	325-328
Number of pages	4
ISBN (Electronic)	9781728172309
DOIs	https://doi.org/10.1109/NEMS50311.2020.9265570
State	Published - Sep 27 2020
Externally published	Yes
Event	15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020 - Virtual, San Diego, United States Duration: Sep 27 2020 → Sep 30 2020

Publication series

Name	15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020

Conference

Conference	15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
Country/Territory	United States
City	Virtual, San Diego
Period	9/27/20 → 9/30/20

Keywords

flexural rigidity
growth rate
localization precision
microtubules

ASJC Scopus subject areas

Biotechnology
Molecular Biology
Electrochemistry
Biomedical Engineering
Electronic, Optical and Magnetic Materials
Instrumentation

Access to Document

10.1109/NEMS50311.2020.9265570

Cite this

Zhou, H., Isozaki, N., Ukita, K., Hawkins, T. L., Ross, J. L., & Yokokawa, R. (2020). Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate. In 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020 (pp. 325-328). Article 9265570 (15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS50311.2020.9265570

Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate. / Zhou, Hang; Isozaki, Naoto; Ukita, Kazuki et al.
15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 325-328 9265570 (15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020).

Research output: Chapter in Book/Entry/Poem › Conference contribution

Zhou, H, Isozaki, N, Ukita, K, Hawkins, TL, Ross, JL & Yokokawa, R 2020, Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate. in 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020., 9265570, 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020, Institute of Electrical and Electronics Engineers Inc., pp. 325-328, 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020, Virtual, San Diego, United States, 9/27/20. https://doi.org/10.1109/NEMS50311.2020.9265570

Zhou H, Isozaki N, Ukita K, Hawkins TL, Ross JL, Yokokawa R. Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate. In 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 325-328. 9265570. (15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020). doi: 10.1109/NEMS50311.2020.9265570

Zhou, Hang ; Isozaki, Naoto ; Ukita, Kazuki et al. / Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate. 15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 325-328 (15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020).

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abstract = "Microtubules (MTs) are highly dynamic tubular biopolymers, involving in many cellular processes such as intracellular transport, cellular structure maintenance, and cell division. All the processes require that MTs have adequate and adjustable flexural rigidity to cope with different functions. Despite the importance of MT mechanics, previously reported values of MTs' flexural rigidity vary significantly. Here we provide an explanation for such a longstanding discrepancy. Moreover, with the localization precision optimized to the nanometer-level, we find that the flexural rigidity of MTs is dependent on growth rate. Not only do our results show the importance of localization precision on flexural rigidity studies, but also highlight the significance of the MT growth rate.",

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AU - Ross, Jennifer L.

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Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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