Flexural Rigidity of Microtubules Measured by Gold Stripe-Patterned Substrate

Hang Zhou, Naoto Isozaki, Kazuki Ukita, Taviare L. Hawkins, Jennifer L. Ross, Ryuji Yokokawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microtubules (MTs) are highly dynamic tubular biopolymers, involving in many cellular processes such as intracellular transport, cellular structure maintenance, and cell division. All the processes require that MTs have adequate and adjustable flexural rigidity to cope with different functions. Despite the importance of MT mechanics, previously reported values of MTs' flexural rigidity vary significantly. Here we provide an explanation for such a longstanding discrepancy. Moreover, with the localization precision optimized to the nanometer-level, we find that the flexural rigidity of MTs is dependent on growth rate. Not only do our results show the importance of localization precision on flexural rigidity studies, but also highlight the significance of the MT growth rate.

Original languageEnglish (US)
Title of host publication15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages325-328
Number of pages4
ISBN (Electronic)9781728172309
DOIs
StatePublished - Sep 27 2020
Event15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020 - Virtual, San Diego, United States
Duration: Sep 27 2020Sep 30 2020

Publication series

Name15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020

Conference

Conference15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
CountryUnited States
CityVirtual, San Diego
Period9/27/209/30/20

Keywords

  • flexural rigidity
  • growth rate
  • localization precision
  • microtubules

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Electrochemistry
  • Biomedical Engineering
  • Electronic, Optical and Magnetic Materials
  • Instrumentation

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