Finite-element method for intermodality nonrigid breast registration using external skin markers

Ioana L. Coman, Andrzej Krol, James A. Mandel, Karl G. Baum, Min Luo, Edward D. Lipson, David H. Feiglin

Research output: Contribution to journalConference Articlepeer-review

1 Scopus citations


We are developing a method using nonrigid co-registration of PET and MR breast images as a way to improve diagnostic specificity in difficult-to-interpret mammograms, and ultimately to avoid biopsy. A deformable breast model based on a finite-element method (FEM) has been employed. The EEM "loads" are taken as the observed intermodality displacements of several fiducial skin markers placed on the breast and visible in PET and MRI. The analogy between orthogonal components of the displacement field and the temperature differences in a steady-state heat transfer (SSHT) in solids has been adopted. The model allows estimation, throughout the breast, of the intermodality displacement field. To test our model, an elastic breast phantom with simulated internal "lesions" and external markers was imaged with PET and MRI. We have estimated fiducial- and target-registration errors vs. number and location of fiducials, and have shown that the SSHT approach using external fiducial markers is accurate to within ∼5 mm.

Original languageEnglish (US)
Pages (from-to)1152-1155
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5370 II
StatePublished - 2004
EventProgress in Biomedical Optics and Imaging - Medical Imaging 2004: Imaging Processing - San Diego, CA, United States
Duration: Feb 16 2004Feb 19 2004


  • Finite element method
  • Multimodality imaging
  • Nonrigid registration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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