TY - JOUR
T1 - Facilitation of time-dependent memory processes with posttrial epinephrine injections
AU - Gold, Paul E.
AU - Van Buskirk, Roderick B.
N1 - Funding Information:
These experiments, along with the extensive studies of posttrial treatments which interfere with memory processes (cf. Jarvik, 1972; McGaugh and 1Supported by Research Grants MH12526 and MH25384, Training Grant MH11095 from the National Institute of Mental Health, and by Research Grant GB42746 from the National Science Foundation. 2Now at Department of Biological Sciences, Stanford University, Stanford, California. 3We gratefully acknowledge the assistance of Dr. James L. McGaugh for his generous support of this research.
PY - 1975/2
Y1 - 1975/2
N2 - This experiment examined the effect of posttraining epinephrine injections on memory-storage processes. Rats were trained with a weak footshock (0.7 mA, 0.35 sec) on a one-trial inhibitory avoidance task. The animals received epinephrine injections immediately, 10 min, 30 min, or 2 hr after training. On a retention test 24 hr after training, animals which received subcutaneous injections of epinephrine (0.01, 0.05, or 0.1 mg/kg) immediately after training had retention performance which was significantly better than that of saline control animals. A lower (0.001 mg/kg) or a higher (0.5 mg/kg) dose did not affect retention performance. Epinephrine injections (0.1 mg/kg) given 10 min after training also significantly facilitated retention, but injections given 30 min or 2 hr after training did not affect retention performance significantly. These findings suggest that the hormonal consequences of a training experience (e.g., epinephrine release) may normally modulate memory-storage processes in untreated animals.
AB - This experiment examined the effect of posttraining epinephrine injections on memory-storage processes. Rats were trained with a weak footshock (0.7 mA, 0.35 sec) on a one-trial inhibitory avoidance task. The animals received epinephrine injections immediately, 10 min, 30 min, or 2 hr after training. On a retention test 24 hr after training, animals which received subcutaneous injections of epinephrine (0.01, 0.05, or 0.1 mg/kg) immediately after training had retention performance which was significantly better than that of saline control animals. A lower (0.001 mg/kg) or a higher (0.5 mg/kg) dose did not affect retention performance. Epinephrine injections (0.1 mg/kg) given 10 min after training also significantly facilitated retention, but injections given 30 min or 2 hr after training did not affect retention performance significantly. These findings suggest that the hormonal consequences of a training experience (e.g., epinephrine release) may normally modulate memory-storage processes in untreated animals.
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U2 - 10.1016/S0091-6773(75)91784-8
DO - 10.1016/S0091-6773(75)91784-8
M3 - Article
C2 - 1122202
AN - SCOPUS:0016441344
SN - 1074-7427
VL - 13
SP - 145
EP - 153
JO - Communications in behavioral biology. Part A: [Original articles]
JF - Communications in behavioral biology. Part A: [Original articles]
IS - 2
ER -