Abstract
This experiment examined the effect of posttraining epinephrine injections on memory-storage processes. Rats were trained with a weak footshock (0.7 mA, 0.35 sec) on a one-trial inhibitory avoidance task. The animals received epinephrine injections immediately, 10 min, 30 min, or 2 hr after training. On a retention test 24 hr after training, animals which received subcutaneous injections of epinephrine (0.01, 0.05, or 0.1 mg/kg) immediately after training had retention performance which was significantly better than that of saline control animals. A lower (0.001 mg/kg) or a higher (0.5 mg/kg) dose did not affect retention performance. Epinephrine injections (0.1 mg/kg) given 10 min after training also significantly facilitated retention, but injections given 30 min or 2 hr after training did not affect retention performance significantly. These findings suggest that the hormonal consequences of a training experience (e.g., epinephrine release) may normally modulate memory-storage processes in untreated animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-153 |
| Number of pages | 9 |
| Journal | Behavioral Biology |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
- Medicine(all)
Cite this
Facilitation of time-dependent memory processes with posttrial epinephrine injections. / Gold, Paul Ernest; Van Buskirk, Roderick B.
In: Behavioral Biology, Vol. 13, No. 2, 1975, p. 145-153.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Facilitation of time-dependent memory processes with posttrial epinephrine injections
AU - Gold, Paul Ernest
AU - Van Buskirk, Roderick B.
PY - 1975
Y1 - 1975
N2 - This experiment examined the effect of posttraining epinephrine injections on memory-storage processes. Rats were trained with a weak footshock (0.7 mA, 0.35 sec) on a one-trial inhibitory avoidance task. The animals received epinephrine injections immediately, 10 min, 30 min, or 2 hr after training. On a retention test 24 hr after training, animals which received subcutaneous injections of epinephrine (0.01, 0.05, or 0.1 mg/kg) immediately after training had retention performance which was significantly better than that of saline control animals. A lower (0.001 mg/kg) or a higher (0.5 mg/kg) dose did not affect retention performance. Epinephrine injections (0.1 mg/kg) given 10 min after training also significantly facilitated retention, but injections given 30 min or 2 hr after training did not affect retention performance significantly. These findings suggest that the hormonal consequences of a training experience (e.g., epinephrine release) may normally modulate memory-storage processes in untreated animals.
AB - This experiment examined the effect of posttraining epinephrine injections on memory-storage processes. Rats were trained with a weak footshock (0.7 mA, 0.35 sec) on a one-trial inhibitory avoidance task. The animals received epinephrine injections immediately, 10 min, 30 min, or 2 hr after training. On a retention test 24 hr after training, animals which received subcutaneous injections of epinephrine (0.01, 0.05, or 0.1 mg/kg) immediately after training had retention performance which was significantly better than that of saline control animals. A lower (0.001 mg/kg) or a higher (0.5 mg/kg) dose did not affect retention performance. Epinephrine injections (0.1 mg/kg) given 10 min after training also significantly facilitated retention, but injections given 30 min or 2 hr after training did not affect retention performance significantly. These findings suggest that the hormonal consequences of a training experience (e.g., epinephrine release) may normally modulate memory-storage processes in untreated animals.
UR - http://www.scopus.com/inward/record.url?scp=0016441344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016441344&partnerID=8YFLogxK
U2 - 10.1016/S0091-6773(75)91784-8
DO - 10.1016/S0091-6773(75)91784-8
M3 - Article
C2 - 1122202
AN - SCOPUS:0016441344
VL - 13
SP - 145
EP - 153
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 2
ER -