Expression of tumor suppressor genes in channel catfish after bacterial infections

Weijie Mu, Jun Yao, Jiaren Zhang, Shikai Liu, Haishen Wen, Jianbin Feng, Zhanjiang Liu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Tumor suppressor genes are negative regulators of tumor formation. While their anti-tumor functions have been well studied, they have been found to be also involved in immune responses and innate immunity. In this study, 21 tumor suppressor genes in channel catfish (Ictalurus punctatus) were characterized. Phylogenetic and syntenic analyses allowed annotation of all 21 catfish tumor suppressor genes. The expression profiles of the 21 catfish tumor suppressor genes were determined using the RNA-Seq datasets. After Edwardsiella ictaluri infection, expression of five of the 21 tumor suppressor genes was up-regulated at 3 days in the intestine, and four of the 21 genes were up-regulated in the liver 14 days post-infection. With Flavobacterium columnare infection, seven genes were up-regulated in the gill at 48 h post-infection. These results expanded our knowledge on the tumor suppressor genes in teleosts, setting a foundation for future studies to unravel functions of tumor suppressor genes in response to stresses, particularly after bacterial disease infections.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalDevelopmental and Comparative Immunology
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Disease infection
  • Expression
  • Fish
  • Genome
  • P53
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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