Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes

Katherine Murphy, Luis Carvajal, Leo Medico, Melissa Pepling

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The Signal transducers and activators of transcription (Stat) family of proteins plays diverse roles during differentiation in many tissues. Stat3 is an essential mammalian gene, critical during embryonic development. In mammals, Stat3 is differentially distributed in the cytoplasm of mature oocytes and in preimplantation embryos suggesting that Stat3 may be involved in determination of polarity. Here, we report that Stat3 protein is expressed in the cytoplasm of oocytes from primordial, primary and secondary follicles in the adult ovary and in developing acrosomes of round spermatids in the adult testis. Stat3 is also expressed in gonocytes, prospermatogonia, oogonia and oocytes of embryonic and neonatal gonads.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalGene Expression Patterns
Issue number4
StatePublished - Apr 2005


  • Gamete biology
  • Jak-Stat signaling
  • Mouse
  • Oocyte development
  • Oogenesis
  • Ovary
  • Spermatogenesis
  • Spermiogenesis
  • Stat3
  • Testes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology


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