Abstract
Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.
| Original language | English (US) |
|---|---|
| Title of host publication | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Print) | 9781479983605 |
| DOIs | |
| State | Published - Jun 2 2015 |
| Event | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015 |
Other
| Other | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 |
|---|---|
| Country | United States |
| City | Troy |
| Period | 4/17/15 → 4/19/15 |
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ASJC Scopus subject areas
- Biotechnology
- Cancer Research
- Cell Biology
- Molecular Medicine
- Biomedical Engineering
- Control and Systems Engineering
Cite this
Wang, J., & Henderson, J. H. (2015). Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 [7117134] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117134