Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility

J. Wang; James H Henderson

doi:10.1109/NEBEC.2015.7117134

Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility

J. Wang, James H Henderson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.

Original language	English (US)
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117134
State	Published - Jun 2 2015
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Other

Other	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country	United States
City	Troy
Period	4/17/15 → 4/19/15

ASJC Scopus subject areas

Biotechnology
Cancer Research
Cell Biology
Molecular Medicine
Biomedical Engineering
Control and Systems Engineering

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Wang, J & Henderson, JH 2015, Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117134, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117134

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abstract = "Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.",

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N2 - Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.

AB - Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.

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ER -

Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility

Abstract

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