Experimental and theoretical studies on the morphogenesis of bacterial biofilms

Cheng Zhang, Bo Li, Jing Ying Tang, Xiao Ling Wang, Zhao Qin, Xi Qiao Feng

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Biofilm morphogenesis not only reflects the physiological state of bacteria but also serves as a strategy to sustain bacterial survival. In this paper, we take the Bacillus subtilis colony as a model system to explore the morphomechanics of growing biofilms confined in a defined geometry. We find that the growth-induced stresses may drive the occurrence of both surface wrinkling and interface delamination in the biofilm, leading to the formation of a labyrinthine network on its surface. The wrinkles are perpendicular to the boundary of the constraint region. The variation in the surface undulations is attributed to the spatial stress field, which is isotropic in the inner regime but anisotropic in the vicinity of the boundary. Our experiments show that the directional surface wrinkles can confer biofilms with anisotropic wetting properties. This study not only highlights the role of mechanics in sculpturing organisms within the morphogenetic context but also suggests a promising route toward desired surfaces at the interface between synthetic biology and materials sciences.

Original languageEnglish (US)
Pages (from-to)7389-7397
Number of pages9
JournalSoft Matter
Volume13
Issue number40
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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  • Cite this

    Zhang, C., Li, B., Tang, J. Y., Wang, X. L., Qin, Z., & Feng, X. Q. (2017). Experimental and theoretical studies on the morphogenesis of bacterial biofilms. Soft Matter, 13(40), 7389-7397. https://doi.org/10.1039/c7sm01593c