Expanding monomeric pyrophosphate complexes beyond platinum

Nadia Marino, Anthony R. Vortherms, Amanda E. Hoffman, Robert Patrick Doyle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and {[Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]}'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls.

Original languageEnglish (US)
Pages (from-to)6790-6792
Number of pages3
JournalInorganic Chemistry
Volume49
Issue number15
DOIs
StatePublished - Aug 2 2010

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Platinum
cultured cells
Stoichiometry
Doxorubicin
Cisplatin
stoichiometry
platinum
cancer
Cells
diphosphoric acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Expanding monomeric pyrophosphate complexes beyond platinum. / Marino, Nadia; Vortherms, Anthony R.; Hoffman, Amanda E.; Doyle, Robert Patrick.

In: Inorganic Chemistry, Vol. 49, No. 15, 02.08.2010, p. 6790-6792.

Research output: Contribution to journalArticle

Marino, N, Vortherms, AR, Hoffman, AE & Doyle, RP 2010, 'Expanding monomeric pyrophosphate complexes beyond platinum', Inorganic Chemistry, vol. 49, no. 15, pp. 6790-6792. https://doi.org/10.1021/ic1006007
Marino, Nadia ; Vortherms, Anthony R. ; Hoffman, Amanda E. ; Doyle, Robert Patrick. / Expanding monomeric pyrophosphate complexes beyond platinum. In: Inorganic Chemistry. 2010 ; Vol. 49, No. 15. pp. 6790-6792.
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