Expanding monomeric pyrophosphate complexes beyond platinum

Nadia Marino, Anthony R. Vortherms, Amanda E. Hoffman, Robert P. Doyle

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and {[Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]}'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls.

Original languageEnglish (US)
Pages (from-to)6790-6792
Number of pages3
JournalInorganic Chemistry
Volume49
Issue number15
DOIs
StatePublished - Aug 2 2010

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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