Expanding monomeric pyrophosphate complexes beyond platinum

Nadia Marino; Anthony R. Vortherms; Amanda E. Hoffman; Robert P. Doyle

doi:10.1021/ic1006007

Expanding monomeric pyrophosphate complexes beyond platinum

Nadia Marino, Anthony R. Vortherms, Amanda E. Hoffman, Robert P. Doyle

Research output: Contribution to journal › Article › peer-review

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Abstract

Four new monomeric pyrophosphate complexes, namely [Co(phen) ₂(H ₂P ₂O ₇)]̇4H ₂O (1'4H ₂O), [Ni(phen) ₂(H ₂P ₂O ₇)]'8H ₂O (2'8H ₂O), [Cu(phen)(H ₂O)(H ₂P ₂O ₇)] (3) and {[Cu(phen)(H ₂O)(P ₂O ₇)][Na ₂(H ₂O) ₈]}'6H ₂O (4'14H ₂O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC ₅₀ values, compared to μM IC ₅₀ values for cisplatin controls.

Original language	English (US)
Pages (from-to)	6790-6792
Number of pages	3
Journal	Inorganic Chemistry
Volume	49
Issue number	15
DOIs	https://doi.org/10.1021/ic1006007
State	Published - Aug 2 2010

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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@article{557bee41bb354f37a752dc59d293bab3,

title = "Expanding monomeric pyrophosphate complexes beyond platinum",

abstract = "Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7){\.]}4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and {[Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]}'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls.",

author = "Nadia Marino and Vortherms, {Anthony R.} and Hoffman, {Amanda E.} and Doyle, {Robert P.}",

year = "2010",

month = aug,

day = "2",

doi = "10.1021/ic1006007",

language = "English (US)",

volume = "49",

pages = "6790--6792",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "15",

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TY - JOUR

T1 - Expanding monomeric pyrophosphate complexes beyond platinum

AU - Marino, Nadia

AU - Vortherms, Anthony R.

AU - Hoffman, Amanda E.

AU - Doyle, Robert P.

PY - 2010/8/2

Y1 - 2010/8/2

N2 - Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and {[Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]}'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls.

AB - Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and {[Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]}'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls.

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JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 15

ER -

Expanding monomeric pyrophosphate complexes beyond platinum

Abstract

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