Estimated pulse wave velocity and incident heart failure and its subtypes: Findings from the multi-ethnic study of atherosclerosis

Kevin S. Heffernan, Daniela Charry, Jing Xu, Hirofumi Tanaka, James R. Churilla

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Age-associated increase in aortic stiffness, measured as carotid-femoral pulse wave velocity (PWV), is an important effector of cardiac damage and heart failure (HF). Pulse wave velocity estimated from age and blood pressure (ePWV) is emerging as a useful proxy of vascular aging and subsequent cardiovascular disease risk. We examined the association of ePWV with incident HF and its subtypes in a large community sample of 6814 middle-aged and older adults from the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Participants with an ejection fraction ≤40 % were classified as HF with reduced ejection fraction (HFrEF) while those with an ejection fraction ≥50 % were classified as HF with preserved ejection fraction (HFpEF). Cox proportional hazards regression models were used to calculate hazard ratios (HR) and 95 % confidence intervals (CI). Results: Over a mean follow-up period of 12.5 years, incident HF was diagnosed in 339 participants: 165 were classified as HFrEF and 138 as HFpEF. In fully adjusted models, the highest quartile of ePWV was significantly associated with an increased risk of overall HF (HR 4.79, 95 % CI 2.43–9.45) compared with the lowest quartile (reference). When exploring HF subtypes, the highest quartile of ePWV was associated with HFrEF (HR 8.37, 95 % CI 4.24–16.52) and HFpEF (HR 3.94, 95 % CI 1.39–11.17). Conclusions: Higher ePWV values were associated with higher rates of incident HF and its subtypes in a large, diverse cohort of men and women.

Original languageEnglish (US)
Article number100238
JournalAmerican Heart Journal Plus: Cardiology Research and Practice
Volume25
DOIs
StatePublished - Jan 2023

Keywords

  • Epidemiology
  • Heart failure
  • MESA
  • Pulse wave velocity
  • Vascular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Estimated pulse wave velocity and incident heart failure and its subtypes: Findings from the multi-ethnic study of atherosclerosis'. Together they form a unique fingerprint.

Cite this