TY - JOUR
T1 - Estimated Pulse Wave Velocity and All-Cause Mortality
T2 - Findings from the Health and Retirement Study
AU - Heffernan, Kevin S.
AU - Wilmoth, Janet M.
AU - London, Andrew S.
N1 - Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America.
PY - 2022
Y1 - 2022
N2 - Background and Objectives: The gold standard method for the assessment of vascular aging is carotid-femoral pulse wave velocity (cfPWV). cfPWV can be estimated from 2 commonly assessed clinical variables-age and blood pressure. This analysis uses data from the Health and Retirement Study to examine the relationship between estimated pulse wave velocity (ePWV) and mortality among 9,293 middle age and older adults. Research Design and Methods: Cox proportional hazard models were used to predict mortality occurring over a 10-to 12-year period. Controls were included for sociodemographic characteristics (age, gender, race, ethnicity, wealth, income, and education), health status (history of cardiovascular disease [CVD], diabetes, and stroke and related medication use), health behaviors (smoking, physical activity, and body mass index), and CVD-related biomarkers (systolic and diastolic blood pressure, C-reactive protein, cystatin c, hemoglobin A1c, total cholesterol, and high-density lipoprotein cholesterol). Results: By 2018, 26.19% of the weighted analytic sample were reported as deceased. In the fully specified models that control for age, age-squared, systolic and diastolic blood pressure, sociodemographic variables, health status and behaviors, and biomarkers, ePWV was associated with a greater likelihood of mortality. Discussion and Implications: An estimate of PWV derived from age and blood pressure is independently associated with an increased likelihood of death in a representative sample of middle age and older adults in the United States.
AB - Background and Objectives: The gold standard method for the assessment of vascular aging is carotid-femoral pulse wave velocity (cfPWV). cfPWV can be estimated from 2 commonly assessed clinical variables-age and blood pressure. This analysis uses data from the Health and Retirement Study to examine the relationship between estimated pulse wave velocity (ePWV) and mortality among 9,293 middle age and older adults. Research Design and Methods: Cox proportional hazard models were used to predict mortality occurring over a 10-to 12-year period. Controls were included for sociodemographic characteristics (age, gender, race, ethnicity, wealth, income, and education), health status (history of cardiovascular disease [CVD], diabetes, and stroke and related medication use), health behaviors (smoking, physical activity, and body mass index), and CVD-related biomarkers (systolic and diastolic blood pressure, C-reactive protein, cystatin c, hemoglobin A1c, total cholesterol, and high-density lipoprotein cholesterol). Results: By 2018, 26.19% of the weighted analytic sample were reported as deceased. In the fully specified models that control for age, age-squared, systolic and diastolic blood pressure, sociodemographic variables, health status and behaviors, and biomarkers, ePWV was associated with a greater likelihood of mortality. Discussion and Implications: An estimate of PWV derived from age and blood pressure is independently associated with an increased likelihood of death in a representative sample of middle age and older adults in the United States.
KW - Cardiovascular disease
KW - Estimated pulse wave velocity
KW - Mortality
KW - Vascular aging
KW - Vascular stiffness
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U2 - 10.1093/geroni/igac056
DO - 10.1093/geroni/igac056
M3 - Article
AN - SCOPUS:85147038005
SN - 2399-5300
VL - 6
JO - Innovation in Aging
JF - Innovation in Aging
IS - 7
M1 - igac056
ER -