Abstract
The present study examined the relative importance of α- and β-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhancef retention performance of a one-trial inhibitory avoidance respone. Further pretraning injections of a variety of adrenoceptor antagonists, including selective α1-,α2, β1- and /or β2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that α- and β-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.
Original language | English (US) |
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Pages (from-to) | 189-193 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 129 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 23 1986 |
Externally published | Yes |
Keywords
- (Rat)
- Adrenoceptor antagonists
- Epinephrine
- Inhibitory avoidance
- Memory facilitation
ASJC Scopus subject areas
- Pharmacology