TY - JOUR
T1 - Epinephrine-induced memory facilitation
T2 - attenuation by adrenoceptor antagonists
AU - Sternberg, Debra B.
AU - Korol, Donna
AU - Novack, Gary D.
AU - McGaugh, James L.
PY - 1986/9/23
Y1 - 1986/9/23
N2 - The present study examined the relative importance of α- and β-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhancef retention performance of a one-trial inhibitory avoidance respone. Further pretraning injections of a variety of adrenoceptor antagonists, including selective α1-,α2, β1- and /or β2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that α- and β-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.
AB - The present study examined the relative importance of α- and β-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhancef retention performance of a one-trial inhibitory avoidance respone. Further pretraning injections of a variety of adrenoceptor antagonists, including selective α1-,α2, β1- and /or β2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that α- and β-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.
KW - (Rat)
KW - Adrenoceptor antagonists
KW - Epinephrine
KW - Inhibitory avoidance
KW - Memory facilitation
UR - http://www.scopus.com/inward/record.url?scp=0022545570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022545570&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90353-5
DO - 10.1016/0014-2999(86)90353-5
M3 - Article
C2 - 2876904
AN - SCOPUS:0022545570
VL - 129
SP - 189
EP - 193
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -