Epinephrine-induced memory facilitation: attenuation by adrenoceptor antagonists

Debra B. Sternberg; Donna Korol; Gary D. Novack; James L. McGaugh

doi:10.1016/0014-2999(86)90353-5

Epinephrine-induced memory facilitation: attenuation by adrenoceptor antagonists

Debra B. Sternberg, Donna Korol, Gary D. Novack, James L. McGaugh

Research output: Contribution to journal › Article

41 Scopus citations

Abstract

The present study examined the relative importance of α- and β-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhancef retention performance of a one-trial inhibitory avoidance respone. Further pretraning injections of a variety of adrenoceptor antagonists, including selective α₁-,α₂, β₁- and /or β₂-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that α- and β-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.

Original language	English (US)
Pages (from-to)	189-193
Number of pages	5
Journal	European Journal of Pharmacology
Volume	129
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(86)90353-5
State	Published - Sep 23 1986
Externally published	Yes

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Keywords

(Rat)
Adrenoceptor antagonists
Epinephrine
Inhibitory avoidance
Memory facilitation

ASJC Scopus subject areas

Pharmacology

Cite this

Sternberg, D. B., Korol, D., Novack, G. D., & McGaugh, J. L. (1986). Epinephrine-induced memory facilitation: attenuation by adrenoceptor antagonists. European Journal of Pharmacology, 129(1-2), 189-193. https://doi.org/10.1016/0014-2999(86)90353-5

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10.1016/0014-2999(86)90353-5