Epinephrine-induced memory facilitation: attenuation by adrenoceptor antagonists

Debra B. Sternberg, Donna Korol, Gary D. Novack, James L. McGaugh

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The present study examined the relative importance of α- and β-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhancef retention performance of a one-trial inhibitory avoidance respone. Further pretraning injections of a variety of adrenoceptor antagonists, including selective α1-,α2, β1- and /or β2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that α- and β-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalEuropean Journal of Pharmacology
Volume129
Issue number1-2
DOIs
StatePublished - Sep 23 1986
Externally publishedYes

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Keywords

  • (Rat)
  • Adrenoceptor antagonists
  • Epinephrine
  • Inhibitory avoidance
  • Memory facilitation

ASJC Scopus subject areas

  • Pharmacology

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