Epigenetic regulation of the maize Spm transposon

Nina Fedoroff, Michael Schläppi, Ramesh Raina

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Expression and transposition of the Suppressor-mutator (Spm) transposon of maize are controlled by interacting epigenetic and autoregulatory mechanisms. Methylation of critical element sequences prevents both transcription and transposition, heritably inactivating the element. The promoter, comprising the terminal 0.2 kb of the element, and a 0.35-kb, highly GC-rich, downstream sequence are the methylation target sequences. The element encodes two proteins necessary for transposition, TnpA and TnpD. There are multiple TnpA binding sites, both in the 5′ terminal promoter region and at the element's 3′ end. In addition to its role in transposition, TnpA is both a positive and a negative regulator of transcription. TnpA represses the element's promoter when it is not methylated. When the element is inactive and its promoter methylated, TnpA activates the methylated promoter and facilitates both its transient and heritable demethylation.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalBioEssays
Volume17
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Methylation
Transcription
Epigenomics
epigenetics
transposons
transposition (genetics)
Zea mays
promoter regions
GC Rich Sequence
corn
Genetic Promoter Regions
methylation
Binding Sites
Proteins
binding sites
transcription factors
transcription (genetics)
proteins

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Fedoroff, N., Schläppi, M., & Raina, R. (1995). Epigenetic regulation of the maize Spm transposon. BioEssays, 17(4), 291-297.

Epigenetic regulation of the maize Spm transposon. / Fedoroff, Nina; Schläppi, Michael; Raina, Ramesh.

In: BioEssays, Vol. 17, No. 4, 1995, p. 291-297.

Research output: Contribution to journalArticle

Fedoroff, N, Schläppi, M & Raina, R 1995, 'Epigenetic regulation of the maize Spm transposon', BioEssays, vol. 17, no. 4, pp. 291-297.
Fedoroff N, Schläppi M, Raina R. Epigenetic regulation of the maize Spm transposon. BioEssays. 1995;17(4):291-297.
Fedoroff, Nina ; Schläppi, Michael ; Raina, Ramesh. / Epigenetic regulation of the maize Spm transposon. In: BioEssays. 1995 ; Vol. 17, No. 4. pp. 291-297.
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