Epigenetic control of germline development

Priscilla M. Van Wynsberghe, Eleanor M. Maine

Research output: Chapter in Book/Entry/PoemChapter

6 Scopus citations


Dynamic regulation of histone modifications and small noncoding RNAs is observed throughout the development of the C. elegans germ line. Histone modifications are differentially regulated in the mitotic vs meiotic germ line, on X chromosomes vs autosomes and on paired chromosomes vs unpaired chromosomes. Small RNAs function in transposon silencing and developmental gene regulation. Histone modifications and small RNAs produced in the germ line can be inherited and impact embryonic development. Disruption of histone-modifying enzymes or small RNA machinery in the germ line can result in sterility due to degeneration of the germ line and/or an inability to produce functional gametes.

Original languageEnglish (US)
Title of host publicationGerm Cell Development in C. elegans
PublisherSpringer Science and Business Media, LLC
Number of pages31
ISBN (Print)9781461440147
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • C. elegans
  • Chromatin
  • Epigenetic
  • Germ line
  • Histone
  • MES complex
  • Meiotic silencing
  • PiRNA
  • SiRNA
  • Small RNA

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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