Epigenetic control of germline development

Priscilla M. Van Wynsberghe, Eleanor M. Maine

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Dynamic regulation of histone modifications and small noncoding RNAs is observed throughout the development of the C. elegans germ line. Histone modifications are differentially regulated in the mitotic vs meiotic germ line, on X chromosomes vs autosomes and on paired chromosomes vs unpaired chromosomes. Small RNAs function in transposon silencing and developmental gene regulation. Histone modifications and small RNAs produced in the germ line can be inherited and impact embryonic development. Disruption of histone-modifying enzymes or small RNA machinery in the germ line can result in sterility due to degeneration of the germ line and/or an inability to produce functional gametes.

Original languageEnglish (US)
Title of host publicationGerm Cell Development in C. elegans
EditorsTim Schedl
Pages373-403
Number of pages31
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume757
ISSN (Print)0065-2598

Keywords

  • C. elegans
  • Chromatin
  • Epigenetic
  • Germ line
  • Histone
  • MES complex
  • Meiotic silencing
  • PiRNA
  • SiRNA
  • Small RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Van Wynsberghe, P. M., & Maine, E. M. (2013). Epigenetic control of germline development. In T. Schedl (Ed.), Germ Cell Development in C. elegans (pp. 373-403). (Advances in Experimental Medicine and Biology; Vol. 757). https://doi.org/10.1007/978-1-4614-4015-4-13