Epidemiology of Genotype 1 and 2 Hepatitis E Virus Infections

Kenrad E. Nelson, Alain B. Labrique, Brittany Kmush

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Hepatitis E virus (HEV) genotypes 1 and 2 are responsible for the majority of acute viral hepatitis infections in endemic areas in South Asia and sub-Saharan Africa. In addition to frequent sporadic illnesses throughout the year, these viruses often cause large epidemics in association with monsoon rains in Asia or during humanitarian crises in Africa. Clinical hepatitis commonly involves adults more often than young children, with an overall mortality of ∼1%. However, the mortality among pregnant women is often 30% or higher. HEV infection in pregnant women frequently leads to infant mortality or premature delivery. Hepatitis E is an important, yet largely neglected, global public health problem.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in medicine
Volume9
Issue number6
DOIs
StatePublished - Jun 3 2019

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Hepatitis E virus
Epidemiology
Virus Diseases
Viruses
Hepatitis
Pregnant Women
Genotype
Hepatitis E
Rain
Mortality
Africa South of the Sahara
Infant Mortality
Public Health
Public health
Medical problems
Global Health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Epidemiology of Genotype 1 and 2 Hepatitis E Virus Infections. / Nelson, Kenrad E.; Labrique, Alain B.; Kmush, Brittany.

In: Cold Spring Harbor perspectives in medicine, Vol. 9, No. 6, 03.06.2019.

Research output: Contribution to journalReview article

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AB - Hepatitis E virus (HEV) genotypes 1 and 2 are responsible for the majority of acute viral hepatitis infections in endemic areas in South Asia and sub-Saharan Africa. In addition to frequent sporadic illnesses throughout the year, these viruses often cause large epidemics in association with monsoon rains in Asia or during humanitarian crises in Africa. Clinical hepatitis commonly involves adults more often than young children, with an overall mortality of ∼1%. However, the mortality among pregnant women is often 30% or higher. HEV infection in pregnant women frequently leads to infant mortality or premature delivery. Hepatitis E is an important, yet largely neglected, global public health problem.

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