Enzyme-Responsive Shape Memory Polymers

James Henderson (Inventor), Patrick Mather (Inventor), Shelby Buffington (Inventor)

Research output: Patent


An enzyme responsive shape memory polymer formed from a glassy, cross-linked shape memory polymer that incorporates ester bonds that are responsive to the present of an enzyme. PCL-based polyurethanes (featuring simple alternation of PCL diol and lysine-based diisocyanate) are degradable by Amano lipase PS. A non-degradable thermoplastic elastomer may be dual electrospun with a polycaprolactone based TPU with the fixing phase compressed so that the composite is ready for enzymatically triggered contraction. Alternatively, the elastomer may be a PCL copolymer-based polyurethane amorphous elastomer that is both degradable and elastomeric and put into compression so that upon enzymatic degradation of the elastomeric phase the scaffold expands.
Original languageEnglish (US)
Patent number11,512,417
Priority date3/28/18
Filing date3/28/19
StatePublished - Oct 3 2019


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