Enzymatically triggered shape memory polymers direct cell alignment

Shelby L. Buffington, Mathew M. Ali, Patrick T. Mather, James H Henderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose Shape memory polymers (SMPs) have emerged as powerful platforms to study how cells respond to precise changes in their mechanical microenvironment. SMPs are a class of smart materials that change their shape in response to a stimulus, such as heat or hydration. Previously we have developed an SMP that responds to enzymatic activity that could enable SMPs to respond to physiological conditions in vivo, such as the presence of pathological cells.[1] The goal of this study was to study cell morphological and behavioral changes in response to enzymatically triggered shape changes that occur under isothermal conditions.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Buffington, S. L., Ali, M. M., Mather, P. T., & Henderson, J. H. (2019). Enzymatically triggered shape memory polymers direct cell alignment. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.