(Figure Presented) Ru cat. = variety of second generation Grubbs' catalysts used nine examples, 92-99% isolated yields Angle strain in methylene cyclobutane was used to drive a cross-enyne metathesis with 1-alkynes, giving 1,1,3-trisubstituted 1,3-dienes in good isolated yields. An extensive survey of Grubbs' second-generation catalysts led to an optimized reaction conducted at 0 °C.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry