Enyne cross-metathesis with strained, geminally-substituted alkenes: Direct access to highly substituted 1,3-dienes

Daniel A. Clark, Brenda S. Basile, William S. Karnofel, Steven T. Diver

Research output: Contribution to journalArticle

21 Scopus citations


(Figure Presented) Ru cat. = variety of second generation Grubbs' catalysts used nine examples, 92-99% isolated yields Angle strain in methylene cyclobutane was used to drive a cross-enyne metathesis with 1-alkynes, giving 1,1,3-trisubstituted 1,3-dienes in good isolated yields. An extensive survey of Grubbs' second-generation catalysts led to an optimized reaction conducted at 0 °C.

Original languageEnglish (US)
Pages (from-to)4927-4929
Number of pages3
JournalOrganic Letters
Issue number21
StatePublished - 2008
Externally publishedYes


ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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