Transmembrane (TM) β-peptides comprised of acyclic β3-amino acids demonstrate equilibrium between 12- and 14-helical structures in an environment- and sequence-dependent manner. Circular dichroism (CD) spectra of TM β3-peptides may be described as linear combinations of the 12- and 14-helical CD spectra. The apparent malleability of β3-substituted acyclic β-peptides has practical implications for foldamer design, as it suggests that both the 14-helix and 12-helix might be reasonable platforms for molecular recognition.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry