Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer

Kai Cheng; Steven R. Blumen; Maximilian B. MacPherson; Jeremy L. Steinbacher; Brooke T. Mossman; Christopher C. Landry

doi:10.1021/am100530t

Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer

Kai Cheng, Steven R. Blumen, Maximilian B. MacPherson, Jeremy L. Steinbacher, Brooke T. Mossman, Christopher C. Landry

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.

Original language	English (US)
Pages (from-to)	2489-2495
Number of pages	7
Journal	ACS Applied Materials and Interfaces
Volume	2
Issue number	9
DOIs	https://doi.org/10.1021/am100530t
State	Published - Sep 22 2010
Externally published	Yes

Keywords

biomedical applications
drug delivery
porous materials
silica
surface modification

ASJC Scopus subject areas

General Materials Science

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10.1021/am100530t

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abstract = "Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.",

keywords = "biomedical applications, drug delivery, porous materials, silica, surface modification",

author = "Kai Cheng and Blumen, {Steven R.} and MacPherson, {Maximilian B.} and Steinbacher, {Jeremy L.} and Mossman, {Brooke T.} and Landry, {Christopher C.}",

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AU - Cheng, Kai

AU - Blumen, Steven R.

AU - MacPherson, Maximilian B.

AU - Steinbacher, Jeremy L.

AU - Mossman, Brooke T.

AU - Landry, Christopher C.

PY - 2010/9/22

Y1 - 2010/9/22

N2 - Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.

AB - Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.

KW - biomedical applications

KW - drug delivery

KW - porous materials

KW - silica

KW - surface modification

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Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer

Abstract

Keywords

ASJC Scopus subject areas

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