Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer

Kai Cheng, Steven R. Blumen, Maximilian B. MacPherson, Jeremy L. Steinbacher, Brooke T. Mossman, Christopher C. Landry

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.

Original languageEnglish (US)
Pages (from-to)2489-2495
Number of pages7
JournalACS Applied Materials and Interfaces
Volume2
Issue number9
DOIs
StatePublished - Sep 22 2010

Keywords

  • biomedical applications
  • drug delivery
  • porous materials
  • silica
  • surface modification

ASJC Scopus subject areas

  • Materials Science(all)

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