Energy barriers and cell migration in densely packed tissues

Dapeng Bi, Jorge H. Lopez, Jennifer M Schwarz, Mary Elizabeth Manning

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Recent observations demonstrate that confluent tissues exhibit features of glassy dynamics, such as caging behavior and dynamical heterogeneities, although it has remained unclear how single-cell properties control this behavior. Here we develop numerical and theoretical models to calculate energy barriers to cell rearrangements, which help govern cell migration in cell monolayers. In contrast to work on sheared foams, we find that energy barrier heights are exponentially distributed and depend systematically on the cell's number of neighbors. Based on these results, we predict glassy two-time correlation functions for cell motion, with a timescale that increases rapidly as cell activity decreases. These correlation functions are used to construct simple random walks that reproduce the caging behavior observed for cell trajectories in experiments. This work provides a theoretical framework for predicting collective motion of cells in wound-healing, embryogenesis and cancer tumorogenesis.

Original languageEnglish (US)
Pages (from-to)1885-1890
Number of pages6
JournalSoft Matter
Volume10
Issue number12
DOIs
StatePublished - Mar 28 2014

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Energy barriers
Tissue
cells
Foams
Monolayers
Trajectories
energy
Experiments
wound healing
random walk
foams
cancer
trajectories

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Energy barriers and cell migration in densely packed tissues. / Bi, Dapeng; Lopez, Jorge H.; Schwarz, Jennifer M; Manning, Mary Elizabeth.

In: Soft Matter, Vol. 10, No. 12, 28.03.2014, p. 1885-1890.

Research output: Contribution to journalArticle

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