Effects of reserpine on retention of escape reversal in mice

Absence of state dependent learning

P. Kurtz, T. Palfai

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

A discriminated escape training paradigm was used to study the effects of reserpine on learning and memory in mice. Intraperitoneal injection of reserpine before reversal training had no effect on acquisition but did produce a time- and dose-dependent impairment of retention test performance 10 days later. These results suggested that reserpine may have interfered with some aspect of memory storage. Retention impairments observed when a 2.0 mg/kg reserpine injection was given 2 hr before reversal training were not attenuated by readministering the drug before testing, a finding that provides no support for a state-dependency interpretation. Furthermore, animals treated with reserpine exhibited inferior retention of previous training, regardless of the pharmacological state present during that learning. This was interpreted as a drug-induced impairment of memory retrieval. In addition, performance during the initial discriminated escape training session suggested that reserpine may also impair acquisition under some conditions. In the last experiment, it was found that when the catecholamine precursor L-dihydroxyphenylalanine (100 mg/kg) and the indole amine precursor D,L-5-hydroxytryptophan (125 mg/kg) were both given after reserpine treatment, subsequent retention performance was not significantly impaired. The results are discussed in terms of the possible roles of biogenic amines in arousal, learning, and memory.

Original languageEnglish (US)
Title of host publicationJournal of Comparative and Physiological Psychology
Pages393-406
Number of pages14
Volume91
Edition2
StatePublished - 1977
Externally publishedYes

Fingerprint

Reserpine
Learning
5-Hydroxytryptophan
Dihydroxyphenylalanine
Biogenic Amines
Retention (Psychology)
Arousal
Intraperitoneal Injections
Pharmaceutical Preparations
Catecholamines
Amines
Pharmacology
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kurtz, P., & Palfai, T. (1977). Effects of reserpine on retention of escape reversal in mice: Absence of state dependent learning. In Journal of Comparative and Physiological Psychology (2 ed., Vol. 91, pp. 393-406)

Effects of reserpine on retention of escape reversal in mice : Absence of state dependent learning. / Kurtz, P.; Palfai, T.

Journal of Comparative and Physiological Psychology. Vol. 91 2. ed. 1977. p. 393-406.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kurtz, P & Palfai, T 1977, Effects of reserpine on retention of escape reversal in mice: Absence of state dependent learning. in Journal of Comparative and Physiological Psychology. 2 edn, vol. 91, pp. 393-406.
Kurtz P, Palfai T. Effects of reserpine on retention of escape reversal in mice: Absence of state dependent learning. In Journal of Comparative and Physiological Psychology. 2 ed. Vol. 91. 1977. p. 393-406
Kurtz, P. ; Palfai, T. / Effects of reserpine on retention of escape reversal in mice : Absence of state dependent learning. Journal of Comparative and Physiological Psychology. Vol. 91 2. ed. 1977. pp. 393-406
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