@article{dfd5145337ee45689e05354b0ce1bf96,
title = "Effects of polygenic risk and perceived friends{\textquoteright} drinking and disruptive behavior on development of alcohol use across adolescence",
abstract = "Objective: Developmental theory posits interacting individual and contextual factors that contribute to alcohol use across adolescence. Despite the well-documented salience of peer environmental influences on adolescent drinking, it is not known whether peer environments moderate polygenic risks for trajectories of alcohol use. The current theoretically based investigation aimed to test developmental gene–environment interaction (G×E) effects across adolescence. Method: Latent growth curve models tested interactive associations of polygenic risk scores and adolescents{\textquoteright} perceived friend drinking and disruptive behavior with adolescents{\textquoteright} initial level of alcohol use frequency at age 16 years old and change in alcohol frequency from ages 16 to 20. The sample comprised 8,941 White adolescents (49% female) from Great Britain within the Avon Longitudinal Study of Parents and Children (ALSPAC). Results: Greater polygenic risk was associated with more frequent initial drinking as well as escalations in drinking frequency over the subsequent 5 years in latent growth curve models. Contrary to study hypotheses, no significant G×E effects were identified after controlling for confounding main and interaction effects. Conclusions: Adolescents at heightened genetic risk may accelerate their alcohol use across adolescence, although not significantly more so in the presence of these alcohol-promoting peer environments. Future well-powered, theoretically driven replication efforts are needed to examine generalizability of these findings across diverse samples.",
author = "Zaso, {Michelle J.} and Maisto, {Stephen A.} and Glatt, {Stephen J.} and Aesoon Park",
note = "Funding Information: funding is available on the ALSPAC website (http://www.bristol.ac.uk/ alspac/external/documents/grant-acknowledgements.pdf); this research was specifically funded by NIH Grant 5R01AA018333-05 and the Wellcome Trust and MRC (Grant ref.: 092731). Genome-wide association study data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. *Correspondence may be sent to Aesoon Park at the Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, or via email at: aepark@syr.edu. Funding Information: This work was supported by National Institutes of Health (NIH) Grants F31 AA025833 to Michelle J. Zaso and R15 AA022496 and R01 AA027677 to Aesoon Park, as well as research funds from Syracuse University. Preparation of this article was supported by the National Institute on Alcohol Abuse and Alcoholism (T32 AA007583) in support of Michelle J. Zaso. The U.K. Medical Research Council (MRC) and Wellcome (Grant ref.: 102215/2/13/2) and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). A comprehensive list of grant Funding Information: This work was supported by National Institutes of Health (NIH) Grants F31 AA025833 to Michelle J. Zaso and R15 AA022496 and R01 AA027677 to Aesoon Park, as well as research funds from Syracuse University. Preparation of this article was supported by the National Institute on Alcohol Abuse and Alcoholism (T32 AA007583) in support of Michelle J. Zaso. The U.K. Medical Research Council (MRC) and Wellcome (Grant ref.: 102215/2/13/2) and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/ alspac/external/documents/grant-acknowledgements.pdf); this research was specifically funded by NIH Grant 5R01AA018333-05 and the Wellcome Trust and MRC (Grant ref.: 092731). Genome-wide association study data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. Publisher Copyright: {\textcopyright} 2020, Alcohol Research Documentation Inc.. All rights reserved.",
year = "2020",
month = nov,
doi = "10.15288/jsad.2020.81.808",
language = "English (US)",
volume = "81",
pages = "808--815",
journal = "Journal of studies on alcohol and drugs",
issn = "1937-1888",
publisher = "Alcohol Research Documentation, Inc.",
number = "6",
}