Effects of material properties on bacterial adhesion and biofilm formation

F. Song, H. Koo, D. Ren

Research output: Contribution to journalReview articlepeer-review

411 Scopus citations


Adhesion of microbes, such as bacteria and fungi, to surfaces and the subsequent formation of biofilms cause multidrug-tolerant infections in humans and fouling of medical devices. To address these challenges, it is important to understand how material properties affect microbe-surface interactions and engineer better nonfouling materials. Here we review the recent progresses in this field and discuss the main challenges and opportunities. In particular, we focus on bacterial biofilms and review the effects of surface energy, charge, topography, and stiffness of substratum material on bacterial adhesion. We summarize how these surface properties influence oral biofilm formation, and we discuss the important findings from nondental systems that have potential applications in dental medicine.

Original languageEnglish (US)
Pages (from-to)1027-1034
Number of pages8
JournalJournal of Dental Research
Issue number8
StatePublished - Aug 25 2015


  • bacteria
  • biofouling
  • biomaterials
  • dental implants
  • dentistry
  • infection control

ASJC Scopus subject areas

  • General Dentistry


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