Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels

Tibor Palfai; Lawrence Wichlinski; H. Alex Brown; Oliver M. Brown

doi:10.1016/0091-3057(86)90210-8

Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels

Tibor Palfai, Lawrence Wichlinski, H. Alex Brown, Oliver M. Brown

Department of Psychology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectromery. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.

Original language	English (US)
Pages (from-to)	1457-1459
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(86)90210-8
State	Published - May 1986

Keywords

Acetylcholine
Amnesia
Mouse brain
Rauwolfia alkaloids
Reserpine

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(86)90210-8

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abstract = "The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectromery. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.",

keywords = "Acetylcholine, Amnesia, Mouse brain, Rauwolfia alkaloids, Reserpine",

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AU - Palfai, Tibor

AU - Wichlinski, Lawrence

AU - Alex Brown, H.

AU - Brown, Oliver M.

PY - 1986/5

Y1 - 1986/5

N2 - The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectromery. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.

AB - The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectromery. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.

KW - Acetylcholine

KW - Amnesia

KW - Mouse brain

KW - Rauwolfia alkaloids

KW - Reserpine

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Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels

Abstract

Keywords

ASJC Scopus subject areas

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