Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels

Tibor Palfai, Lawrence Wichlinski, H. Alex Brown, Oliver M. Brown

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectromery. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.

Original languageEnglish (US)
Pages (from-to)1457-1459
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume24
Issue number5
DOIs
StatePublished - May 1986

Keywords

  • Acetylcholine
  • Amnesia
  • Mouse brain
  • Rauwolfia alkaloids
  • Reserpine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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