TY - JOUR
T1 - Effectiveness of zinc oxide nanoparticles against helminthiasis
T2 - A preliminary investigation conducted on pheretima posthuma
AU - Hosain, Faruk
AU - Islam, Md Shafiul
AU - Ragib, Abdullah Al
AU - Islam, Muhammad Zukaul
AU - Islam, Tariqul
N1 - Funding Information:
The authors are indebted to the Department of Applied Chemistry and Chemical Engineering, NSTU and BCSIR, Bangladesh for the laboratory support of this research work.
Publisher Copyright:
© 2021 Growing Science Ltd. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Based on paralyzed and death time, zinc oxide (ZnO) nanoparticles (NPs) were preliminarily investigated for possible biological effectiveness of anthelmintic activity on Pheretima Posthuma. After synthesizing ZnO NPs by low-temperature precipitation method with slight modification, size, morphology, and shape evaluation of these nanoparticles were characterized by scanning electron microscopy and annealing temperature in the range 400-700 ℃. In this anthelmintic assay, the paralyzed time (PT) was gradually shorter with the increase of the sample concentration, for instance, when high concentration (40mg/ml) sample was applied on adult worms the paralyzed time was 35.6 minutes only. The death time (DT) was 450 and 80 minutes when the sample concentration was 20 and 40 mg/ml respectively. These results were compared with albendazole as a reference showed PT and DT 378.6 and 402.3 minutes, respectively, and showed maximum dose-dependent anthelmintic activity. Finally, at higher concentration paralytic effect (PE) was showed much earlier and subsequently, it is important to note that the time taken for death observation was shorter.
AB - Based on paralyzed and death time, zinc oxide (ZnO) nanoparticles (NPs) were preliminarily investigated for possible biological effectiveness of anthelmintic activity on Pheretima Posthuma. After synthesizing ZnO NPs by low-temperature precipitation method with slight modification, size, morphology, and shape evaluation of these nanoparticles were characterized by scanning electron microscopy and annealing temperature in the range 400-700 ℃. In this anthelmintic assay, the paralyzed time (PT) was gradually shorter with the increase of the sample concentration, for instance, when high concentration (40mg/ml) sample was applied on adult worms the paralyzed time was 35.6 minutes only. The death time (DT) was 450 and 80 minutes when the sample concentration was 20 and 40 mg/ml respectively. These results were compared with albendazole as a reference showed PT and DT 378.6 and 402.3 minutes, respectively, and showed maximum dose-dependent anthelmintic activity. Finally, at higher concentration paralytic effect (PE) was showed much earlier and subsequently, it is important to note that the time taken for death observation was shorter.
KW - Antihelminthic potential
KW - Death time
KW - Paralyzed time
KW - Pheretima posthuman
KW - ZnO nanoparticles
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U2 - 10.5267/j.ccl.2020.9.001
DO - 10.5267/j.ccl.2020.9.001
M3 - Article
AN - SCOPUS:85100942431
VL - 10
SP - 81
EP - 88
JO - Current Chemistry Letters
JF - Current Chemistry Letters
SN - 1927-7296
IS - 2
ER -