TY - JOUR
T1 - Effect of one year of thiazide therapy on plasma volume, renin, aldosterone, lipids and urinary metanephrines in systolic hypertension of elderly patients
AU - Vardan, Suman
AU - Dunsky, Milton H.
AU - Hill, Norma E.
AU - Mehrotra, Kishan G.
AU - Mookherjee, Saktipada
AU - Smulyan, Harold
AU - Warner, Robert A.
N1 - Funding Information:
From the Cardiology, General Medicine, and Nuclear Medicine Sections, Department of Medicine, Veterans Administration Medical Center, and the Health Science Centers, State University of New York and School of Computer and Information Science, Syracuse University, Syracuse, New York. This work was supported by the Veterans Administration and by Grant RR-229 from the pivision of Research Resources, National Institutes of Health, Bethesda, Maryland. Manuscript received January 20,’ 1987; revised manuscript received and accepted April 7, 1987.
PY - 1987/8/1
Y1 - 1987/8/1
N2 - Increased cardiac and vascular morbidity and mortality are known to accompany systemic systolic hypertension of the elderly. We have reported on the hemodynamic benefit in this disorder after 1 month of therapy with a thiazide diuretic, and on the maintenance of improvement for 1 year.1 In another group of patients with systolic hypertension we have reported on the changes in plasma volume, renin activity, and aldosterone, lipid and urinary metanephrine levels at 1 month of such therapy.2 This study extends these observations to 1 year of thiazide therapy and explores the relation between the hemodynamic and biochemical variables during this period.
AB - Increased cardiac and vascular morbidity and mortality are known to accompany systemic systolic hypertension of the elderly. We have reported on the hemodynamic benefit in this disorder after 1 month of therapy with a thiazide diuretic, and on the maintenance of improvement for 1 year.1 In another group of patients with systolic hypertension we have reported on the changes in plasma volume, renin activity, and aldosterone, lipid and urinary metanephrine levels at 1 month of such therapy.2 This study extends these observations to 1 year of thiazide therapy and explores the relation between the hemodynamic and biochemical variables during this period.
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U2 - 10.1016/0002-9149(87)90256-6
DO - 10.1016/0002-9149(87)90256-6
M3 - Article
C2 - 3303891
AN - SCOPUS:0023273588
SN - 0002-9149
VL - 60
SP - 388
EP - 390
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 4
ER -