Effect of drugs on consolidation of classically conditioned fear

Tibor Palfai, James M. Cornell

Research output: Contribution to journalArticle

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Abstract

Effects of a posttrial injection of nembutal, chlorpromazine, or metrazol on classically conditioned fear was examined in 162 rats. Evidence of amnesia was observed when seizures were induced by metrazol immediately following the conditioning trial. Amnesia was not produced by other drugs, by subconvulsive doses of metrazol, or by metrazol seizures induced 24 hr. after training. When present, amnesia was still evident 1 wk. later. These results are consistent with a consolidation hypothesis. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)584-589
Number of pages6
JournalJournal of Comparative and Physiological Psychology
Volume66
Issue number3 PART 1
DOIs
StatePublished - Dec 1968
Externally publishedYes

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Keywords

  • nembutal vs. chlorpromazine vs. metrazol, classically conditioned fear, rat

ASJC Scopus subject areas

  • Medicine(all)

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