Effect of cardiorespiratory fitness on acute inflammation induced increases in arterial stiffness in older adults

Sae Young Jae, Eun Sun Yoon, Soo Jin Jung, Sol Gi Jung, Soo Hyun Park, Byung Sung Kim, Kevin S. Heffernan, Bo Fernhall

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We tested the hypothesis that acute inflammation may cause arterial stiffening in older adults. We further explored if high cardiorespiratory fitness may partially prevent the unfavorable effect of arterial stiffening produced by acute systemic inflammation in older adults. Using a randomized double-blind sham placebo-controlled design, forty healthy older adults were assigned to receive either an influenza vaccine or a sham vaccine. C-reactive protein and interleukin 6 (IL-6) were measured as markers of inflammation. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIX) as indices of arterial stiffness and wave reflection were assessed at baseline and 24 and 48 h after each vaccination. When compared with sham placebo, the influenza vaccination caused a significant increase in CRP (p < 0.05) and IL-6 (p < 0.05). Carotid-femoral PWV, but not AIX was significantly increased after influenza vaccination (p < 0.05), but not sham vaccination. The high cardiorespiratory fitness group had an attenuated increase in PWV as compared to the low cardiorespiratory fitness group after acute inflammation (p < 0.05). These findings show that acute inflammation may cause significant increases in arterial stiffness in older adults, but these increases were attenuated in the high cardiorespiratory fitness group as compared to the low cardiorespiratory fitness group.

Original languageEnglish (US)
Pages (from-to)2159-2166
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume113
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Arterial stiffness
  • Cardiorespiratory fitness
  • Exercise
  • Inflammation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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