Abstract
Independent groups of mice were treated with an amnesic dose of either reserpine, syrosingopine or guanethidine. The animals were sacrificed either 2 or 24 hrs later. While reserpine depleted the levels of whole brain dopamine and norepinephrine at both times syrosingopine or guanethidine did not appreciably deplete these catecholamines at either time. Since all three drugs produce amnesia when given 2 hrs before passive avoidance training, it appears that the levels of whole brain catecholamines at the time of training do not predict the probability of memory formation.
Original language | English (US) |
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Pages (from-to) | 911-914 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1981 |
Keywords
- Amnesia
- Biogenic amines
- Dopamine
- Guanethidin
- Norepinephrine
- Rauwolfia alkaloids
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience