Effect of an amnesic dose of reserpine, syrosingopine or guanethidine on the levels of whole brain dopamine and norepinephrine in the mouse

Oliver M. Brown, Tibor Palfai, Lawrence Wichlinski

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Independent groups of mice were treated with an amnesic dose of either reserpine, syrosingopine or guanethidine. The animals were sacrificed either 2 or 24 hrs later. While reserpine depleted the levels of whole brain dopamine and norepinephrine at both times syrosingopine or guanethidine did not appreciably deplete these catecholamines at either time. Since all three drugs produce amnesia when given 2 hrs before passive avoidance training, it appears that the levels of whole brain catecholamines at the time of training do not predict the probability of memory formation.

Original languageEnglish (US)
Pages (from-to)911-914
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume15
Issue number6
DOIs
StatePublished - Dec 1981

    Fingerprint

Keywords

  • Amnesia
  • Biogenic amines
  • Dopamine
  • Guanethidin
  • Norepinephrine
  • Rauwolfia alkaloids

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this