Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice

Tibor Palfai; Virginia H. Felleman

doi:10.1016/0091-3057(82)90295-7

Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice

Tibor Palfai, Virginia H. Felleman

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

In three experiments, behavioral toxicity induced by 5 different dose levels of digitoxin was investigated in mice that were treated with either clonidine or propranolol or were either young (70-140 days), middle aged (240-260) or old (450-600). Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED₅₀ and the LD₅₀. The results were discussed in terms of adrenergic mechanisms mediating digitoxin toxicity. Aged mice were found to be the least and middle aged the most resistant to the toxic effects of digitoxin.

Original language	English (US)
Pages (from-to)	399-404
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(82)90295-7
State	Published - Sep 1982

Keywords

Behavioral toxicity
Cardioglycosides
Clonidine
Digitalis
Digitoxin
Propranolol

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(82)90295-7

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title = "Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice",

abstract = "In three experiments, behavioral toxicity induced by 5 different dose levels of digitoxin was investigated in mice that were treated with either clonidine or propranolol or were either young (70-140 days), middle aged (240-260) or old (450-600). Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50. The results were discussed in terms of adrenergic mechanisms mediating digitoxin toxicity. Aged mice were found to be the least and middle aged the most resistant to the toxic effects of digitoxin.",

keywords = "Behavioral toxicity, Cardioglycosides, Clonidine, Digitalis, Digitoxin, Propranolol",

author = "Tibor Palfai and Felleman, {Virginia H.}",

note = "Funding Information: 'This research was partially supported by Syracuse University Senate Research Grant (T.P.) and the Gerontology Center, Syracuse University (V. H. F.). Send reprint requests to first author. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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doi = "10.1016/0091-3057(82)90295-7",

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AU - Palfai, Tibor

AU - Felleman, Virginia H.

N1 - Funding Information: 'This research was partially supported by Syracuse University Senate Research Grant (T.P.) and the Gerontology Center, Syracuse University (V. H. F.). Send reprint requests to first author. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1982/9

Y1 - 1982/9

N2 - In three experiments, behavioral toxicity induced by 5 different dose levels of digitoxin was investigated in mice that were treated with either clonidine or propranolol or were either young (70-140 days), middle aged (240-260) or old (450-600). Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50. The results were discussed in terms of adrenergic mechanisms mediating digitoxin toxicity. Aged mice were found to be the least and middle aged the most resistant to the toxic effects of digitoxin.

AB - In three experiments, behavioral toxicity induced by 5 different dose levels of digitoxin was investigated in mice that were treated with either clonidine or propranolol or were either young (70-140 days), middle aged (240-260) or old (450-600). Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50. The results were discussed in terms of adrenergic mechanisms mediating digitoxin toxicity. Aged mice were found to be the least and middle aged the most resistant to the toxic effects of digitoxin.

KW - Behavioral toxicity

KW - Cardioglycosides

KW - Clonidine

KW - Digitalis

KW - Digitoxin

KW - Propranolol

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Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice

Abstract

Keywords

ASJC Scopus subject areas

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