Effect of 1-dopa or bromocriptine on feeding and motor behavior of rats with lesions in the globus pallidus

Tibor Palfai; Deborah Armstrong; Carol Lynn Courtney

doi:10.1016/0031-9384(84)90113-6

Effect of 1-dopa or bromocriptine on feeding and motor behavior of rats with lesions in the globus pallidus

Tibor Palfai, Deborah Armstrong, Carol Lynn Courtney

Department of Psychology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Rats were lesioned bilaterally in the globus pallidus (GP) with anodal current or 6-OHDA, and were observed in various motor tests 10 min daily for 3 weeks. Body weight, home cage water and food intakes were recorded daily under two different food accessibility conditions. The lesions produced adipsia, aphagia, loss of body weight and motor impairments which could not be reversed by either 1-dopa or bromocriptine. Animals could be made to recover, however, by making food easily accessible and palatable. The results do not support a "metabolic" role for the GP but support the idea that aphagia, adipsia and mortality is due to motoric impairments produced by the lesion.

Original language	English (US)
Pages (from-to)	283-289
Number of pages	7
Journal	Physiology and Behavior
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0031-9384(84)90113-6
State	Published - Aug 1984

Keywords

1-Dopa
Bromocriptine
Eating
Globus pallidus
Lesions
Locomotor activity

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Access to Document

10.1016/0031-9384(84)90113-6

Cite this

@article{ba0aef0e141f4275a6c2d3fad408dbb1,

title = "Effect of 1-dopa or bromocriptine on feeding and motor behavior of rats with lesions in the globus pallidus",

abstract = "Rats were lesioned bilaterally in the globus pallidus (GP) with anodal current or 6-OHDA, and were observed in various motor tests 10 min daily for 3 weeks. Body weight, home cage water and food intakes were recorded daily under two different food accessibility conditions. The lesions produced adipsia, aphagia, loss of body weight and motor impairments which could not be reversed by either 1-dopa or bromocriptine. Animals could be made to recover, however, by making food easily accessible and palatable. The results do not support a {"}metabolic{"} role for the GP but support the idea that aphagia, adipsia and mortality is due to motoric impairments produced by the lesion.",

keywords = "1-Dopa, Bromocriptine, Eating, Globus pallidus, Lesions, Locomotor activity",

author = "Tibor Palfai and Deborah Armstrong and Courtney, {Carol Lynn}",

year = "1984",

month = aug,

doi = "10.1016/0031-9384(84)90113-6",

language = "English (US)",

volume = "33",

pages = "283--289",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Effect of 1-dopa or bromocriptine on feeding and motor behavior of rats with lesions in the globus pallidus

AU - Palfai, Tibor

AU - Armstrong, Deborah

AU - Courtney, Carol Lynn

PY - 1984/8

Y1 - 1984/8

N2 - Rats were lesioned bilaterally in the globus pallidus (GP) with anodal current or 6-OHDA, and were observed in various motor tests 10 min daily for 3 weeks. Body weight, home cage water and food intakes were recorded daily under two different food accessibility conditions. The lesions produced adipsia, aphagia, loss of body weight and motor impairments which could not be reversed by either 1-dopa or bromocriptine. Animals could be made to recover, however, by making food easily accessible and palatable. The results do not support a "metabolic" role for the GP but support the idea that aphagia, adipsia and mortality is due to motoric impairments produced by the lesion.

AB - Rats were lesioned bilaterally in the globus pallidus (GP) with anodal current or 6-OHDA, and were observed in various motor tests 10 min daily for 3 weeks. Body weight, home cage water and food intakes were recorded daily under two different food accessibility conditions. The lesions produced adipsia, aphagia, loss of body weight and motor impairments which could not be reversed by either 1-dopa or bromocriptine. Animals could be made to recover, however, by making food easily accessible and palatable. The results do not support a "metabolic" role for the GP but support the idea that aphagia, adipsia and mortality is due to motoric impairments produced by the lesion.

KW - 1-Dopa

KW - Bromocriptine

KW - Eating

KW - Globus pallidus

KW - Lesions

KW - Locomotor activity

UR - http://www.scopus.com/inward/record.url?scp=0021251286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021251286&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(84)90113-6

DO - 10.1016/0031-9384(84)90113-6

M3 - Article

C2 - 6438668

AN - SCOPUS:0021251286

SN - 0031-9384

VL - 33

SP - 283

EP - 289

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 2

ER -

Effect of 1-dopa or bromocriptine on feeding and motor behavior of rats with lesions in the globus pallidus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this