Early-Life Antibiotic Exposure, Gut Microbiota Development, and Predisposition to Obesity

Meghan B. Azad, Shirin Moossavi, Arthur Owora, Shadi Sepehri

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Antibiotics are often prescribed inappropriately to infants and young children, with potentially adverse effects on the developing gut microbiota and related metabolic processes. We review evidence from 17 epidemiologic studies suggesting that antibiotic exposure during critical periods of early development may influence weight gain and the development of obesity. Complementary research in both humans and rodents indicates that gut microbiota play a key role in this process, although further research is needed to confirm and characterize the causal mechanisms involved. Obesity is a complex and multifactorial condition; thus, a multipronged prevention strategy will be required to curb the current obesity epidemic. Evidence to date suggests this strategy should include the judicious use of antibiotics, especially in early life when the developing gut microbiota is particularly susceptible to perturbations with long-lasting implications for metabolic programming and obesity risk.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalNestle Nutrition Institute Workshop Series
Volume88
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Nutrition and Dietetics

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