Dynamic micropattern geometry atop shape memory polymers

Kevin A. Davis, James H. Henderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Substrates micropatterned with cell adhesion proteins have been used to investigate how protein density and geometry affect cell behaviors such as cell migration, growth, and differentiation. Existing technologies are limited in that they typically feature protein micropatterns that are static and unable to change while cells are attached. Here we micropatterned shape memory polymer (SMP) substrates that were capable of transitioning from a stretched state to a contracted state to control the width of patterned lines presented to attached cells. We found that micropattern geometry changed as the SMP substrate transitioned to its unstretched shape. Cells attached to dynamic patterns balled up and contracted their nuclei. The results suggest that micropatterned SMP cell culture substrates can be used to study the temporal aspects of cell mechanobiology.

Original languageEnglish (US)
Title of host publicationProceedings - 39th Annual Northeast Bioengineering Conference, NEBEC 2013
Pages33-34
Number of pages2
DOIs
StatePublished - Nov 8 2013
Event39th Annual Northeast Bioengineering Conference, NEBEC 2013 - Syracuse, NY, United States
Duration: Apr 5 2013Apr 7 2013

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Other

Other39th Annual Northeast Bioengineering Conference, NEBEC 2013
CountryUnited States
CitySyracuse, NY
Period4/5/134/7/13

Keywords

  • biomaterial
  • mechanobiology
  • micropattern
  • stem cells

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Davis, K. A., & Henderson, J. H. (2013). Dynamic micropattern geometry atop shape memory polymers. In Proceedings - 39th Annual Northeast Bioengineering Conference, NEBEC 2013 (pp. 33-34). [6574343] (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). https://doi.org/10.1109/NEBEC.2013.160