TY - JOUR
T1 - DSP4, a noradrenergic neurotoxin, impairs male rats' attraction to conspecific odors
AU - Cornwell-Jones, Catherine A.
N1 - Funding Information:
This research was supported by USPHS Research Grant MH09214 (to C.C.-J.) and MH12526 and Research Contract N00014-84-K-0391 from the Office of Naval Research (to J. L. McGangh). I thank Dr. Norman Weinberger for his assistance in acoustic measurements. Reprint requests should be addressed to: Dr. Catherine Cornwell-Jones, Behavioral Neuroscience Labs, 113 Roney Lane, Syracuse University, Syracuse, NY 13244.
PY - 1988/7
Y1 - 1988/7
N2 - Olfactory investigation was examined in male Sprague-Dawley rats injected with 50 mg/kg of the noradrenergic neurotoxin, DSP4, 10 days before testing. In a two-choice preference test, the odor of pine shavings from the nest of a female and her litter attracted sexually experienced control males, but not drug treated males. Further, odors from anesthetized females increased the mean number of entries made by control males, but not drug-treated males, into a cage containing pups' nest shavings. Combining a novel odor with nest shavings significantly reduced the number of entries made by both groups of males. Drug treatment decreased norepinephrine (NE) levels by 66, 62, and 68% in the olfactory cortex, olfactory bulb, and frontal cortex, respectively. Dopamine concentrations were not significantly affected. NE concentrations in the heart, and serotonin levels in the olfactory bulb, were moderately depleted (by 37 and 40%, respectively). The results support the view that central NE modulates systems regulating attraction to conspecific odors in male rats.
AB - Olfactory investigation was examined in male Sprague-Dawley rats injected with 50 mg/kg of the noradrenergic neurotoxin, DSP4, 10 days before testing. In a two-choice preference test, the odor of pine shavings from the nest of a female and her litter attracted sexually experienced control males, but not drug treated males. Further, odors from anesthetized females increased the mean number of entries made by control males, but not drug-treated males, into a cage containing pups' nest shavings. Combining a novel odor with nest shavings significantly reduced the number of entries made by both groups of males. Drug treatment decreased norepinephrine (NE) levels by 66, 62, and 68% in the olfactory cortex, olfactory bulb, and frontal cortex, respectively. Dopamine concentrations were not significantly affected. NE concentrations in the heart, and serotonin levels in the olfactory bulb, were moderately depleted (by 37 and 40%, respectively). The results support the view that central NE modulates systems regulating attraction to conspecific odors in male rats.
UR - http://www.scopus.com/inward/record.url?scp=0023916660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023916660&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(88)90720-0
DO - 10.1016/S0163-1047(88)90720-0
M3 - Article
C2 - 3401191
AN - SCOPUS:0023916660
SN - 0163-1047
VL - 50
SP - 1
EP - 15
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -