Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers

Ahmed A. Moustafa, Szabolcs Kéri, Bertalan Polner, Corey White

Research output: Contribution to journalArticle

1 Scopus citations


To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Neurogenetics
StateAccepted/In press - Mar 17 2017



  • Alpha-synuclein gene
  • drift diffusion model
  • Parkinson’s disease
  • punishment
  • reinforcement learning
  • reward

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics
  • Cellular and Molecular Neuroscience

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