Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium

M. Kegel, J. T. Tupper

Research output: Contribution to journalArticle

8 Scopus citations


The down regulation of surface membrane receptors for (125I) epidermal growth factor (EGF) has been evaluated in normal and SV40-transformed human fibroblasts (W138) under conditions of serum-supplemented versus defined growth media. Both normal and transformed W138 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum-supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum-supplemented media.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalJournal of Cellular Physiology
Issue number1
StatePublished - 1982


ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

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