Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium

Mark Kegel, Joseph T. Tupper

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The down regulation of surface membrane receptors for(125I) epidermal growth factor (EGF) has been evaluated in normal and SV40‐transformed human fibroblasts (WI38) under conditions of serum‐supplemented versus defined growth media. Both normal and transformed WI38 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum‐supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum‐supplemented media.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalJournal of Cellular Physiology
Volume113
Issue number1
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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