The down regulation of surface membrane receptors for (125I) epidermal growth factor (EGF) has been evaluated in normal and SV40-transformed human fibroblasts (W138) under conditions of serum-supplemented versus defined growth media. Both normal and transformed W138 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum-supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum-supplemented media.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Cellular Physiology|
|State||Published - 1982|
ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry