Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium

M. Kegel, J. T. Tupper

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The down regulation of surface membrane receptors for (125I) epidermal growth factor (EGF) has been evaluated in normal and SV40-transformed human fibroblasts (W138) under conditions of serum-supplemented versus defined growth media. Both normal and transformed W138 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum-supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum-supplemented media.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalJournal of Cellular Physiology
Volume113
Issue number1
StatePublished - 1982

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Epidermal Growth Factor Receptor
Down-Regulation
Recovery
Fibroblasts
Serum
Epidermal Growth Factor
Membranes
HeLa Cells
Growth

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium. / Kegel, M.; Tupper, J. T.

In: Journal of Cellular Physiology, Vol. 113, No. 1, 1982, p. 125-128.

Research output: Contribution to journalArticle

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