TY - JOUR
T1 - Dose-related effects of metrazol on retention and EEG
AU - Palfai, Tibor
AU - Kurtz, Perry
N1 - Funding Information:
A covered Plexiglas m-shaped maze, composed of three 10 x 20 cm arms at right angles to a 50 × l0 cm common alley was used. Guillotine type barriers could be inserted 10 cm from the end of all 3 arms. The metal grid floor of the maze could be electrified throughout except in the two safe boxes at the end of the two side arms. The center arm ~S upported by Research Grant MH-26800-01, from the National Institute of Mental Health, USPHS. ~ Send reprint requests to T. Palfai, Psychology Laboratories, M-15 Lambreth Lane, Syracuse University, Syracuse, New York, 13210. 3 Presently assigned to Toxicology Division, U.S. Army Environmental Hygiene Agency, Aberdeen Proving Ground, MD 21010.
PY - 1976/2
Y1 - 1976/2
N2 - The effects of various dose levels of Metrazol on retention and electrocorticogram (ECoG) were investigated. Mice given a subconvulsive 30 mg/kg or a convulsive 50 mg/kg dose of Metrazol 15 min before reversal training in a discriminated escape learning task showed retention impairment of reversal training retention. Lower dose levels (5 or 10 mg/kg) had no effect. The 30 mg/kg dose produced asymmetrical dissociation. The convulsive dose (50 mg/kg), previously reported to result in symmetrical dissociation, produced ECoG changes that were still evident 15 min following the injection, i.e. at the time when training or testing usually took place. With lower doses (10 or 30 mg/kg), no apparent ECoG effects were observed at this interval. The implications of the findings were discussed with respect to the state-dependent learning hypothesis.
AB - The effects of various dose levels of Metrazol on retention and electrocorticogram (ECoG) were investigated. Mice given a subconvulsive 30 mg/kg or a convulsive 50 mg/kg dose of Metrazol 15 min before reversal training in a discriminated escape learning task showed retention impairment of reversal training retention. Lower dose levels (5 or 10 mg/kg) had no effect. The 30 mg/kg dose produced asymmetrical dissociation. The convulsive dose (50 mg/kg), previously reported to result in symmetrical dissociation, produced ECoG changes that were still evident 15 min following the injection, i.e. at the time when training or testing usually took place. With lower doses (10 or 30 mg/kg), no apparent ECoG effects were observed at this interval. The implications of the findings were discussed with respect to the state-dependent learning hypothesis.
KW - Dissociation
KW - Metrazol
KW - Pentylenetetrazol
KW - State-dependent learning
UR - http://www.scopus.com/inward/record.url?scp=0017226914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017226914&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(76)90003-4
DO - 10.1016/0091-3057(76)90003-4
M3 - Article
C2 - 1265101
AN - SCOPUS:0017226914
SN - 0091-3057
VL - 4
SP - 123
EP - 127
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -