DNA-regulated micro- and nanoparticle assembly

Mathew M. Maye, Dmytro Nykypanchuk, Daniel Van Der Lelie, Oleg Gang

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


The ability to regulate the assembly of DNA-capped micro-and nanoparticles through balanced inter-particle interactions over a broad range of particle sizes and interparticle interaction energies was demonstrated. Both DNA-capped microscale and nanoscale systems consisted of an equipolar mixture of two types of particle, which were functionalized with a composition of complementary linker ssDNA and noncomplementary ssDNA. The surface fraction was controlled through functionalization conditions. The microscale assembly of DNA-capped PS was monitored by optical microscopy. The results show that DNA acts as a steric component, and its can be easily exploited for future interaction fine tuning through DNA-designed recognition, or used as additional sites for more complex multicomponent or multiscale assembly systems.

Original languageEnglish (US)
Pages (from-to)1678-1682
Number of pages5
Issue number10
StatePublished - Oct 2007
Externally publishedYes


  • Colloids
  • DNA
  • Interparticle interactions
  • Nanoparticles
  • Self-assembly

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • General Chemistry
  • General Materials Science


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