DNA mechanical properties: Formulation and comparison with experiments

H. Dalir, T. Nisisako, Y. Yanagida, T. Hatsuzawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A general Newtonian elastic model for both single- and double-stranded DNA is proposed, and an explicit forceextension formula is introduced to characterize their deformations. The effective elastic properties of the DNA backbone are numerically extracted from the ss-DNA experiments. The mechanical properties of long ds-DNA molecules is then studied based on this model, where the base-stacking interactions and the hydrogen bond forces are also considered. Results are obtained by the explicit force-extension formula and good agreement with the single molecule experiments is achieved.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages685-688
Number of pages4
StatePublished - Oct 1 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Publication series

NameTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume3

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

Keywords

  • Base-stacking interactions
  • Double-helical DNA structure
  • Hydrogen bond forces
  • Mechanical properties
  • Single-molecule manipulation

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Dalir, H., Nisisako, T., Yanagida, Y., & Hatsuzawa, T. (2008). DNA mechanical properties: Formulation and comparison with experiments. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 685-688). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 3).